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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
SHBG: biomarker and hepatokine?
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<blockquote data-quote="madman" data-source="post: 201854" data-attributes="member: 13851"><p><strong>Figure 2. <u>Interrelationships between sex hormone-binding globulin (SHBG), total testosterone, and free testosterone and their associations with type 2 diabetes (T2D) and polycystic ovary syndrome (PCOS)</u> [6]. (A–C) In women, Mendelian randomization analyses (A) suggested a causal association of SHBG and free testosterone, but not total testosterone, with T2D (black). In contrast, all variables, including total testosterone, were causally related to PCOS (pink). (B) Genetic variants that affect SHBG in women also affect free testosterone (filled circles), but not total testosterone (open circles). (C) Genetic variants that affect total testosterone in women also affect free testosterone. (D–F) In men, Mendelian randomization analyses (D) suggested a causal association of SHBG and total testosterone, but not free testosterone, with T2D. (E) Genetic variants that affect SHBG also affect total testosterone (open circles) but not free testosterone (filled circles). (F) Genetic variants affecting total testosterone and SHBG levels generally have a neutral effect on free testosterone (green), while genetic variants affecting only total testosterone levels have a positive effect on free testosterone (black). Data are derived from supplementary data of reference [6]. For visualization purposes, two genetic variants have been left out of panel B (rs545206972, MDPU1) and panels E and F (rs6258; SHBG). The effect sizes of these variants are far greater than that of the other genetic variants. BMI, body mass index; OR, odds ratio.</strong></p><p><strong>[ATTACH=full]14527[/ATTACH]</strong></p></blockquote><p></p>
[QUOTE="madman, post: 201854, member: 13851"] [B]Figure 2. [U]Interrelationships between sex hormone-binding globulin (SHBG), total testosterone, and free testosterone and their associations with type 2 diabetes (T2D) and polycystic ovary syndrome (PCOS)[/U] [6]. (A–C) In women, Mendelian randomization analyses (A) suggested a causal association of SHBG and free testosterone, but not total testosterone, with T2D (black). In contrast, all variables, including total testosterone, were causally related to PCOS (pink). (B) Genetic variants that affect SHBG in women also affect free testosterone (filled circles), but not total testosterone (open circles). (C) Genetic variants that affect total testosterone in women also affect free testosterone. (D–F) In men, Mendelian randomization analyses (D) suggested a causal association of SHBG and total testosterone, but not free testosterone, with T2D. (E) Genetic variants that affect SHBG also affect total testosterone (open circles) but not free testosterone (filled circles). (F) Genetic variants affecting total testosterone and SHBG levels generally have a neutral effect on free testosterone (green), while genetic variants affecting only total testosterone levels have a positive effect on free testosterone (black). Data are derived from supplementary data of reference [6]. For visualization purposes, two genetic variants have been left out of panel B (rs545206972, MDPU1) and panels E and F (rs6258; SHBG). The effect sizes of these variants are far greater than that of the other genetic variants. BMI, body mass index; OR, odds ratio. [ATTACH type="full"]14527[/ATTACH][/B] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
SHBG: biomarker and hepatokine?
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