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Testosterone Replacement, Low T, HCG, & Beyond
When Testosterone Is Not Enough
Sexual Dysfunction on TRT
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<blockquote data-quote="Cataceous" data-source="post: 264178" data-attributes="member: 38109"><p>It does seem likely that TRT could affect estrone and estriol. However, they are relatively weak estrogens compared to estradiol, so it would seem to require pretty large deviations to make noticeable symptoms.</p><p></p><p style="margin-left: 20px"><em>In accordance, the estrogenic activity of estrone has been reported to be approximately 4% of that of estradiol.</em>[<a href="https://en.wikipedia.org/wiki/Estrone#Biological_activity" target="_blank">R</a>]</p> <p style="margin-left: 20px"></p> <p style="margin-left: 20px"><em>Although estriol is an efficacious agonist of the ERs, it is reported to have mixed agonist–antagonist (partial agonist) activity at the ER; on its own, it is weakly estrogenic, but in the presence of estradiol, it is antiestrogenic.[8][9] Given by subcutaneous injection in mice, estradiol is about 10-fold more potent than estrone and about 100-fold more potent than estriol.</em>[<a href="https://en.wikipedia.org/wiki/Estriol#Biological_activity" target="_blank">R</a>]</p></blockquote><p></p>
[QUOTE="Cataceous, post: 264178, member: 38109"] It does seem likely that TRT could affect estrone and estriol. However, they are relatively weak estrogens compared to estradiol, so it would seem to require pretty large deviations to make noticeable symptoms. [INDENT][I]In accordance, the estrogenic activity of estrone has been reported to be approximately 4% of that of estradiol.[/I][[URL='https://en.wikipedia.org/wiki/Estrone#Biological_activity']R[/URL]][/INDENT] [INDENT][/INDENT] [INDENT][I]Although estriol is an efficacious agonist of the ERs, it is reported to have mixed agonist–antagonist (partial agonist) activity at the ER; on its own, it is weakly estrogenic, but in the presence of estradiol, it is antiestrogenic.[8][9] Given by subcutaneous injection in mice, estradiol is about 10-fold more potent than estrone and about 100-fold more potent than estriol.[/I][[URL='https://en.wikipedia.org/wiki/Estriol#Biological_activity']R[/URL]][/INDENT] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
When Testosterone Is Not Enough
Sexual Dysfunction on TRT
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