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My theory is the bodies complex hormonal systems are far too intricate to be manipulated long term successfully. A lot of guys after a few years start to have problems such as, flat mood, decreased penile sensitivity, lack of libido and several other problems. The body always finds homeostasis and unfortunately TRT is still very lacking in overcoming this. Just watched a video from Dr Gordon and he states his studies have found initiating TRT affects 35 other hormones. Hopefully in the next few years there will be great strides in TRT.