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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Sex Neurosteroids: hormones made by the brain for the brain
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<blockquote data-quote="madman" data-source="post: 198515" data-attributes="member: 13851"><p><strong>Fig. 2 Estradiol synthesis in response to Ca2+ transients in neurons. (a) Measurements of estradiol by radioimmunoassay in the supernatant of dispersed cultures after various treatments. Short-term treatment with NMDA and with ryanodine at low concentrations, inducing calcium release from internal stores, and with letrozole, phosphorylating aromatase, decreases the release of estradiol into the medium, while U73122/cADPR and ryanodine at high concentrations increase estradiol release by inhibiting calcium release from internal stores. Similarly, thapsigargin, long-term treatment with NMDA (48 h), depleting calcium stores, also increased estradiol secretion into the culture medium. (b) Rescue experiment. Downregulation of estradiol synthesis in response to short-term treatment with NMDA is rescued in the presence of the Ca2+ channel blockers U73122/cADPR.</strong></p><p><strong>[ATTACH=full]13541[/ATTACH]</strong></p></blockquote><p></p>
[QUOTE="madman, post: 198515, member: 13851"] [B]Fig. 2 Estradiol synthesis in response to Ca2+ transients in neurons. (a) Measurements of estradiol by radioimmunoassay in the supernatant of dispersed cultures after various treatments. Short-term treatment with NMDA and with ryanodine at low concentrations, inducing calcium release from internal stores, and with letrozole, phosphorylating aromatase, decreases the release of estradiol into the medium, while U73122/cADPR and ryanodine at high concentrations increase estradiol release by inhibiting calcium release from internal stores. Similarly, thapsigargin, long-term treatment with NMDA (48 h), depleting calcium stores, also increased estradiol secretion into the culture medium. (b) Rescue experiment. Downregulation of estradiol synthesis in response to short-term treatment with NMDA is rescued in the presence of the Ca2+ channel blockers U73122/cADPR. [ATTACH type="full"]13541[/ATTACH][/B] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Sex Neurosteroids: hormones made by the brain for the brain
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