Thank you so much for the support, seriously.

Easily the worst ~6 weeks of my life. I've had food poisoning multiple times, dislocations, "stress" with finances and relationships, but I have never before felt like I was literally losing my mind and personality at the same time. I'm so glad to hear you are back to normal and having great success on regular TRT.

I've had a couple consults with Defy Medical and the depth of their knowledge is really impressive. I have yet to have any treatment from them, but for anyone considering TRT that is definitely the direction I would point them.

That being said, my primary care naturopath recommended another naturopath local to me that specializes in hormone therapy. I met with him in person and was also impressed with his level of knowledge and experience. A couple weeks later, after the replies here hypothesized I may have crashed my estrodial, I sent him a note on his patient portal... Worried, of course, wondering if there's anything I could do, wanting more labs, etc; standard anxious behavior.

He replied to me, on a Sunday no less, and I'm going to share it here because I think it might help someone going through this same sort of thing, which is apparently like the most common issue reported on this forum:

I'm sure there's a bit of coincidence happening as the following Monday was the beginning of my sixth week since getting off of everything, but reading this changed everything for me. "Simply refuse" has become my mantra. Any time I start to feel the stomach clench or the mental discomfort, "Simply refuse." Again, likely a coincidence with the dosage ceasing, but every day since reading that note on Sunday has been significantly better for me. Appetite returning, nearly no anxiety, and a whole lot of hope. Once my anxiety normalizes completely, I'm going to get a comprehensive lab and discuss options with him.

Despite going through this, I do actually believe enclomiphine can work for people and should not be demonized. People just don't bother to post on forums when things go right which totally makes sense. I agree that it is much more likely that it was the high dose anastrozole that ended up doing me in, although the zuclomiphine certainly was not helping. Find a doc that knows their shit. Anyone considering any of this should just reach out to Defy and use them as the standard to compare anyone else to (or just work with them!)

I'll say again that I'm very grateful for this forum. Experts reassuring me that it will pass, others answering questions and citing studies, and others still offering support and compassion. This is what the internet was supposed to be for, so thanks again to everyone.