ExcelMale
Menu
Home
What's new
Latest activity
Forums
New posts
Search forums
What's new
New posts
Latest activity
Videos
Lab Tests
Doctor Finder
Buy Books
About Us
Men’s Health Coaching
Log in
Register
What's new
Search
Search
Search titles only
By:
New posts
Search forums
Menu
Log in
Register
Navigation
Install the app
Install
More options
Contact us
Close Menu
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Serum Testosterone 60 Months after Passive-Scatter Proton Therapy for Localized Prostate Cancer
JavaScript is disabled. For a better experience, please enable JavaScript in your browser before proceeding.
You are using an out of date browser. It may not display this or other websites correctly.
You should upgrade or use an
alternative browser
.
Reply to thread
Message
<blockquote data-quote="madman" data-source="post: 141089" data-attributes="member: 13851"><p><strong><span style="color: rgb(184, 49, 47)">ABSTRACT </span></strong></p><p>Studies demonstrate a decline of 10% in serum testosterone (ST) level after X-ray radio-therapy for prostate cancer. We evaluated changes in ST for patients with low- and intermediate-risk prostate cancer receiving 70-82Gy(RBE) using passive-scatter proton therapy (PT). ST was checked at baseline (n = 358) and at 60 + months after PT (n = 166). The median baseline ST was 363.3 ng/dl (range, 82.0–974.0). The median ST 5 years after PT was 391.5 ng/dl (range, 108.0–1061.0). The difference was not statistically significant (p = 0.9341). Passive-scatter PT was not associated with testosterone suppression at 5 years, suggesting that protons may cause less out-of-field scatter radiation than X-rays.</p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p><strong>Conclusion </strong></p><p>While all eight contemporary trials looking at Xray-based radiotherapy for prostate cancer demonstrate declines in ST, <strong><span style="color: rgb(184, 49, 47)">the current series of 358 patients treated with passive-scatter PT showed no such declines with 5 years of follow-up. </span>The lack of testosterone suppression is presumably due to the 10-fold reduction of secondary dose to the Leydig cells </strong>– consistent with the data published by Yoon et al. (18). <strong><span style="color: rgb(184, 49, 47)">This reduction in secondary dose may ultimately be associated with a lower risk of radiation-induced malignancies, particularly for young patients with substantial life expectancy</span></strong></p></blockquote><p></p>
[QUOTE="madman, post: 141089, member: 13851"] [B][COLOR=rgb(184, 49, 47)]ABSTRACT [/COLOR][/B] Studies demonstrate a decline of 10% in serum testosterone (ST) level after X-ray radio-therapy for prostate cancer. We evaluated changes in ST for patients with low- and intermediate-risk prostate cancer receiving 70-82Gy(RBE) using passive-scatter proton therapy (PT). ST was checked at baseline (n = 358) and at 60 + months after PT (n = 166). The median baseline ST was 363.3 ng/dl (range, 82.0–974.0). The median ST 5 years after PT was 391.5 ng/dl (range, 108.0–1061.0). The difference was not statistically significant (p = 0.9341). Passive-scatter PT was not associated with testosterone suppression at 5 years, suggesting that protons may cause less out-of-field scatter radiation than X-rays. [B]Conclusion [/B] While all eight contemporary trials looking at Xray-based radiotherapy for prostate cancer demonstrate declines in ST, [B][COLOR=rgb(184, 49, 47)]the current series of 358 patients treated with passive-scatter PT showed no such declines with 5 years of follow-up. [/COLOR]The lack of testosterone suppression is presumably due to the 10-fold reduction of secondary dose to the Leydig cells [/B]– consistent with the data published by Yoon et al. (18). [B][COLOR=rgb(184, 49, 47)]This reduction in secondary dose may ultimately be associated with a lower risk of radiation-induced malignancies, particularly for young patients with substantial life expectancy[/COLOR][/B] [/QUOTE]
Insert quotes…
Verification
Post reply
Share this page
Facebook
Twitter
Reddit
Pinterest
Tumblr
WhatsApp
Email
Share
Link
Sponsors
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Serum Testosterone 60 Months after Passive-Scatter Proton Therapy for Localized Prostate Cancer
This site uses cookies to help personalise content, tailor your experience and to keep you logged in if you register.
By continuing to use this site, you are consenting to our use of cookies.
Accept
Learn more…
Top