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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Serum T and Cortisol Concentrations After Single-Dose Administration of 100-Mg Transdermal T in Healthy Men
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<blockquote data-quote="madman" data-source="post: 165958" data-attributes="member: 13851"><p>The growing interest in testosterone's effects on men's social behaviors, in particular aggressive, risk-taking, or status maintenance behaviors, is accompanied by a paucity of dose-dependent pharmacokinetic data. Examining the neurophysiological effects of transdermal testosterone typically includes a 4h delay before further brain-behavior measurements. Nevertheless, high heterogeneity regarding the timing of follow-up measurements and dosage remains. <span style="color: rgb(184, 49, 47)"><strong>In a double-blind placebo-controlled design, we examined the short-term pharmacokinetic profile of 100-mg transdermal testosterone (Testotop®) to determine the optimal time for detecting testosterone-mediated effects.</strong></span> <span style="color: rgb(44, 130, 201)"><strong>Across two studies, 35 healthy men received a single dose of testosterone and placebo in two separate sessions. In study one </strong></span><span style="color: rgb(184, 49, 47)"><strong>(n = 16)</strong></span><span style="color: rgb(44, 130, 201)"><strong>, serum testosterone and cortisol were assessed serially every </strong></span><span style="color: rgb(184, 49, 47)"><strong>30 min up to 2 h posttreatment. </strong></span><span style="color: rgb(44, 130, 201)"><strong>In study two </strong></span><span style="color: rgb(184, 49, 47)"><strong>(n = 19)</strong></span><span style="color: rgb(44, 130, 201)"><strong>, we assessed serum testosterone and cortisol at baseline, </strong></span><span style="color: rgb(184, 49, 47)"><strong>2 h, and 4.15 h (255 min) posttreatment.</strong> </span><span style="color: rgb(44, 130, 201)"><strong>Relative to baseline and placebo, transdermal testosterone significantly increased total serum testosterone concentrations </strong></span><span style="color: rgb(184, 49, 47)"><strong>90 min posttreatment,</strong></span><span style="color: rgb(44, 130, 201)"><strong> reaching maximum concentration between </strong></span><span style="color: rgb(184, 49, 47)"><strong>2 h and 3 h post treatment.</strong></span> <span style="color: rgb(44, 130, 201)"><strong>Albeit elevated, serum testosterone levels gradually decreased between </strong></span><span style="color: rgb(184, 49, 47)"><strong>2 h and 4 h following treatment.</strong></span> <span style="color: rgb(26, 188, 156)"><strong>Transdermal testosterone did not suppress cortisol release. Instead, cortisol concentrations decreased according to cortisol's known circadian rhythm.</strong></span> Unlike previous findings showing significant testosterone concentration increases as soon as 60 min and as late as 3 h post 150- mg testosterone treatment, <span style="color: rgb(184, 49, 47)"><strong>our 100-mg testosterone manipulation significantly increased testosterone concentrations 90 min following treatment. </strong></span>These pharmacokinetic data are important in facilitating the optimization of timing parameters for future testosterone challenge studies.</p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p><strong>In conclusion, we examined the pharmacokinetic profile of a 100-mg transdermal T formulation and found that <span style="color: rgb(184, 49, 47)">it quickly and significantly elevated total serum T levels 90-min posttreatment. </span>Moreover, we found no inhibitory effects of transdermal T on serum C concentrations, the latter decreasing gradually in line with cortisol's independent rhythm. <span style="color: rgb(44, 130, 201)">Therefore, we tentatively suggest that the optimal time-point for examining the association between testosterone and brain-behavior effects with a 100-mg transdermal preparation </span><span style="color: rgb(184, 49, 47)">lies between 1.5 h and 4.15 h following treatment.</span><span style="color: rgb(44, 130, 201)"> Our recommendations are applicable in the context of a transdermal administration route in samples with similar anthropometric characteristics (including age, gender, sexual orientation, and body mass index) as well as similar educational and ethnic backgrounds.</span></strong> <strong>These pharmacokinetic data provide important guidelines for the timing optimization of studies investigating the causal influence of exogenous testosterone on the brain and behavior. </strong></p></blockquote><p></p>
[QUOTE="madman, post: 165958, member: 13851"] The growing interest in testosterone's effects on men's social behaviors, in particular aggressive, risk-taking, or status maintenance behaviors, is accompanied by a paucity of dose-dependent pharmacokinetic data. Examining the neurophysiological effects of transdermal testosterone typically includes a 4h delay before further brain-behavior measurements. Nevertheless, high heterogeneity regarding the timing of follow-up measurements and dosage remains. [COLOR=rgb(184, 49, 47)][B]In a double-blind placebo-controlled design, we examined the short-term pharmacokinetic profile of 100-mg transdermal testosterone (Testotop®) to determine the optimal time for detecting testosterone-mediated effects.[/B][/COLOR] [COLOR=rgb(44, 130, 201)][B]Across two studies, 35 healthy men received a single dose of testosterone and placebo in two separate sessions. In study one [/B][/COLOR][COLOR=rgb(184, 49, 47)][B](n = 16)[/B][/COLOR][COLOR=rgb(44, 130, 201)][B], serum testosterone and cortisol were assessed serially every [/B][/COLOR][COLOR=rgb(184, 49, 47)][B]30 min up to 2 h posttreatment. [/B][/COLOR][COLOR=rgb(44, 130, 201)][B]In study two [/B][/COLOR][COLOR=rgb(184, 49, 47)][B](n = 19)[/B][/COLOR][COLOR=rgb(44, 130, 201)][B], we assessed serum testosterone and cortisol at baseline, [/B][/COLOR][COLOR=rgb(184, 49, 47)][B]2 h, and 4.15 h (255 min) posttreatment.[/B] [/COLOR][COLOR=rgb(44, 130, 201)][B]Relative to baseline and placebo, transdermal testosterone significantly increased total serum testosterone concentrations [/B][/COLOR][COLOR=rgb(184, 49, 47)][B]90 min posttreatment,[/B][/COLOR][COLOR=rgb(44, 130, 201)][B] reaching maximum concentration between [/B][/COLOR][COLOR=rgb(184, 49, 47)][B]2 h and 3 h post treatment.[/B][/COLOR] [COLOR=rgb(44, 130, 201)][B]Albeit elevated, serum testosterone levels gradually decreased between [/B][/COLOR][COLOR=rgb(184, 49, 47)][B]2 h and 4 h following treatment.[/B][/COLOR] [COLOR=rgb(26, 188, 156)][B]Transdermal testosterone did not suppress cortisol release. Instead, cortisol concentrations decreased according to cortisol's known circadian rhythm.[/B][/COLOR] Unlike previous findings showing significant testosterone concentration increases as soon as 60 min and as late as 3 h post 150- mg testosterone treatment, [COLOR=rgb(184, 49, 47)][B]our 100-mg testosterone manipulation significantly increased testosterone concentrations 90 min following treatment. [/B][/COLOR]These pharmacokinetic data are important in facilitating the optimization of timing parameters for future testosterone challenge studies. [B]In conclusion, we examined the pharmacokinetic profile of a 100-mg transdermal T formulation and found that [COLOR=rgb(184, 49, 47)]it quickly and significantly elevated total serum T levels 90-min posttreatment. [/COLOR]Moreover, we found no inhibitory effects of transdermal T on serum C concentrations, the latter decreasing gradually in line with cortisol's independent rhythm. [COLOR=rgb(44, 130, 201)]Therefore, we tentatively suggest that the optimal time-point for examining the association between testosterone and brain-behavior effects with a 100-mg transdermal preparation [/COLOR][COLOR=rgb(184, 49, 47)]lies between 1.5 h and 4.15 h following treatment.[/COLOR][COLOR=rgb(44, 130, 201)] Our recommendations are applicable in the context of a transdermal administration route in samples with similar anthropometric characteristics (including age, gender, sexual orientation, and body mass index) as well as similar educational and ethnic backgrounds.[/COLOR][/B] [B]These pharmacokinetic data provide important guidelines for the timing optimization of studies investigating the causal influence of exogenous testosterone on the brain and behavior. [/B] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Serum T and Cortisol Concentrations After Single-Dose Administration of 100-Mg Transdermal T in Healthy Men
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