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Peptide Forums (GHRH, Sermorelin, etc)
General Peptide Use & Information
Sermorelin - after dinner or before bed?
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<blockquote data-quote="Jasen Bruce" data-source="post: 22480" data-attributes="member: 14"><p>From my understanding, CJC1295 is a modified GhRH similar to Sermorelin but longer acting. </p><p>The DAC (drug affinity complex) sort of forces the GH to release in more of a bell-curve fashion rather than in pulses. In the short term this may be beneficial for healing where static levels of GH can help repair. But I do not believe that DAC is necessary nor should be used long term. Supplementing CJC-1295 (no DAC) with Sermorelin may help increase and stabilize GH production by providing a more constant supply of ghrh in between shorter-actiong Sermorelin injections. My only problem with un approved peptides like CJC1295 is that they are not being made in a licensed pharmacy. There is no way of confirming the quality of the peptide since the raw material is unregulated. I experimented with various peptides and found no additional benefit to just taking a good dosage of Sermorelin by itself. Some of the peptides like GHRP may increase the release of GH initially, but over time tricking the body into releasing more GH will back fire. Also, the hypothalamus-pituitary axis is very sensitive to negative feedback and over stimulation. Taking too much or too many peptides may be counterproductive.</p><p></p><p>Most of our patients use 1000mcg of Sermorelin nightly before bedtime for 6-12 months. Once a follow up serum GH (triple specimen) and IGF-1 confirm a good response, the dosage is often decreased to 500mcg before bedtime to maintain. After GH is optimized and stable, some can reduce the frequency of weekly injections and still maintain. We find in these cases that 2-3 injections per week of 1000mcg maintains optimal response.</p></blockquote><p></p>
[QUOTE="Jasen Bruce, post: 22480, member: 14"] From my understanding, CJC1295 is a modified GhRH similar to Sermorelin but longer acting. The DAC (drug affinity complex) sort of forces the GH to release in more of a bell-curve fashion rather than in pulses. In the short term this may be beneficial for healing where static levels of GH can help repair. But I do not believe that DAC is necessary nor should be used long term. Supplementing CJC-1295 (no DAC) with Sermorelin may help increase and stabilize GH production by providing a more constant supply of ghrh in between shorter-actiong Sermorelin injections. My only problem with un approved peptides like CJC1295 is that they are not being made in a licensed pharmacy. There is no way of confirming the quality of the peptide since the raw material is unregulated. I experimented with various peptides and found no additional benefit to just taking a good dosage of Sermorelin by itself. Some of the peptides like GHRP may increase the release of GH initially, but over time tricking the body into releasing more GH will back fire. Also, the hypothalamus-pituitary axis is very sensitive to negative feedback and over stimulation. Taking too much or too many peptides may be counterproductive. Most of our patients use 1000mcg of Sermorelin nightly before bedtime for 6-12 months. Once a follow up serum GH (triple specimen) and IGF-1 confirm a good response, the dosage is often decreased to 500mcg before bedtime to maintain. After GH is optimized and stable, some can reduce the frequency of weekly injections and still maintain. We find in these cases that 2-3 injections per week of 1000mcg maintains optimal response. [/QUOTE]
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Peptide Forums (GHRH, Sermorelin, etc)
General Peptide Use & Information
Sermorelin - after dinner or before bed?
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