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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
SERM "PCT" Alternatives
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<blockquote data-quote="JustPanicNoDisco" data-source="post: 232102" data-attributes="member: 42100"><p>Fair points. I read through your TRT protocol and the theory behind it. It was definitely interesting. If I recall correctly, you mentioned synthetic GnRH potentially being used as a PCT tool after long-term TRT.</p><p></p><p>Do you see gonadorelin as being a viable PCT alternative in isolation?</p><p></p><p>It is my understanding that tript, at the doses typically used for PCT, causes massive LH spikes (in the paper, it brought blood levels up to ~ 40 mIU/mL). Gonadorelin would seem a much more gentle approach, and would also work from the top down (hypothalamus -> pituitary -> leydig cells), operating similarly to SERMs with respect to end goal, if through a different MOA. I'm just wondering if the GnRH stimulation, at reasonable doses, would be enough to successfully restart the HPTA after a long period of suppression (have been on TRT for about 1.5 years now). It's my understanding that leydig cells become desensitized to LH both in the presence of low LH and high LH (hCG, for instance).</p><p></p><p>I know SERMs are really the gold standard for PCT, but since I a, still dealing with many... "low e2"... issues, I'm trying to think through some potential alternatives, aside from just attempting a fully natural restart, which would be slow and painful, if it recovered levels at all.</p><p></p><p>I haven't really found any data -- even anecdotal -- on such.</p></blockquote><p></p>
[QUOTE="JustPanicNoDisco, post: 232102, member: 42100"] Fair points. I read through your TRT protocol and the theory behind it. It was definitely interesting. If I recall correctly, you mentioned synthetic GnRH potentially being used as a PCT tool after long-term TRT. Do you see gonadorelin as being a viable PCT alternative in isolation? It is my understanding that tript, at the doses typically used for PCT, causes massive LH spikes (in the paper, it brought blood levels up to ~ 40 mIU/mL). Gonadorelin would seem a much more gentle approach, and would also work from the top down (hypothalamus -> pituitary -> leydig cells), operating similarly to SERMs with respect to end goal, if through a different MOA. I'm just wondering if the GnRH stimulation, at reasonable doses, would be enough to successfully restart the HPTA after a long period of suppression (have been on TRT for about 1.5 years now). It's my understanding that leydig cells become desensitized to LH both in the presence of low LH and high LH (hCG, for instance). I know SERMs are really the gold standard for PCT, but since I a, still dealing with many... "low e2"... issues, I'm trying to think through some potential alternatives, aside from just attempting a fully natural restart, which would be slow and painful, if it recovered levels at all. I haven't really found any data -- even anecdotal -- on such. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
SERM "PCT" Alternatives
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