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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Sensitive E2 in the 100’s
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<blockquote data-quote="Cataceous" data-source="post: 198773" data-attributes="member: 38109"><p>We tend to accept the hypothesis that a skewed E2:T ratio is worse than excessive absolute levels, but do we have hard evidence to support that? Maybe there is some work showing that low testosterone in the presence of somewhat high estradiol is problematic... But that doesn't help us evaluate the possible risks of extremely high absolute levels of estradiol. It seems questionable that having similarly high testosterone is going to be protective in all circumstances. I previously touched on some specific concerns <a href="https://www.excelmale.com/forum/threads/estradiol-is-an-important-hormone-for-men.19048/post-193294" target="_blank">here</a>. One of them is the potential for testicular damage:</p><p style="margin-left: 20px"><em><strong>A paradoxical decline in semen parameters in men treated with clomiphene citrate</strong></em></p> <p style="margin-left: 20px"><em>...</em></p> <p style="margin-left: 20px"><em>Elevated estradiol levels result in vacuolization and increased glycoprotein production impairing Sertoli cell function. It also disturbs communication with germ cells, increases collagen synthesis and fatty degeneration in the testicular connective tissue. All these actions collectively result in the induction of germ cell death (Leavy et al., 2017). Oestradiol also plays a critical role in round spermatid chromatin reorganization during spermiogenesis through its action on Estrogen Receptor Alpha (ERα) present on Sertoli cells (Cacciola et al., 2013). Overexposure to estrogens reduces the expression of ERα on Sertoli cells, impacting this critical action. Moreover, it has been recognized that supraphysiological concentrations of estrogen act as powerful apoptotic triggers that induce germ cell apoptosis (Correia et al., 2015).</em></p> <p style="margin-left: 20px">...</p> <p style="margin-left: 20px"><em>Among men who had a decline in semen parameters, 17% of them may not recover following discontinuation of therapy.</em></p><p>[<a href="https://www.excelmale.com/forum/threads/a-paradoxical-decline-in-semen-parameters-in-men-treated-with-clomiphene-citrate-clomid.22076/post-189750" target="_blank">R</a>]</p></blockquote><p></p>
[QUOTE="Cataceous, post: 198773, member: 38109"] We tend to accept the hypothesis that a skewed E2:T ratio is worse than excessive absolute levels, but do we have hard evidence to support that? Maybe there is some work showing that low testosterone in the presence of somewhat high estradiol is problematic... But that doesn't help us evaluate the possible risks of extremely high absolute levels of estradiol. It seems questionable that having similarly high testosterone is going to be protective in all circumstances. I previously touched on some specific concerns [URL='https://www.excelmale.com/forum/threads/estradiol-is-an-important-hormone-for-men.19048/post-193294']here[/URL]. One of them is the potential for testicular damage: [INDENT][I][B]A paradoxical decline in semen parameters in men treated with clomiphene citrate[/B][/I][/INDENT] [INDENT][I]...[/I][/INDENT] [INDENT][I]Elevated estradiol levels result in vacuolization and increased glycoprotein production impairing Sertoli cell function. It also disturbs communication with germ cells, increases collagen synthesis and fatty degeneration in the testicular connective tissue. All these actions collectively result in the induction of germ cell death (Leavy et al., 2017). Oestradiol also plays a critical role in round spermatid chromatin reorganization during spermiogenesis through its action on Estrogen Receptor Alpha (ERα) present on Sertoli cells (Cacciola et al., 2013). Overexposure to estrogens reduces the expression of ERα on Sertoli cells, impacting this critical action. Moreover, it has been recognized that supraphysiological concentrations of estrogen act as powerful apoptotic triggers that induce germ cell apoptosis (Correia et al., 2015).[/I][/INDENT] [INDENT]...[/INDENT] [INDENT][I]Among men who had a decline in semen parameters, 17% of them may not recover following discontinuation of therapy.[/I][/INDENT] [[URL='https://www.excelmale.com/forum/threads/a-paradoxical-decline-in-semen-parameters-in-men-treated-with-clomiphene-citrate-clomid.22076/post-189750']R[/URL]] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Sensitive E2 in the 100’s
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