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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Sensitive E2 in the 100’s
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<blockquote data-quote="JA Battle" data-source="post: 198765" data-attributes="member: 40068"><p>I would tend to agree that if one exceeds Supra-physiological amounts of testosterone, that there should be be a concurrent amount of estradiol to balance competitive activation of various receptors. As to the ratios we’ve widely used on this forum including all posted versions is 14-30 (tt/se2 in their respective different lab units). This puts e2 at 107 pg/ml max for a 1500ng/dl t level. </p><p></p><p>The question is not about the e2 level exclusively. But rather, the testosterone dosage as it is the cause of the high e2. </p><p></p><p>Many men experience varied metabolism of testosterone into its respective metabolites. And this I believe is the cause of men using more t than what we believe would be necessary. </p><p></p><p>The larger issue you elude to being TT (testosterone therapy) vs TRT (testosterone replacement therapy). They are certainly two things and we are both in the same camp with respect to this matter. Replacement constitutes maintaining reference range testosterone at all times. </p><p></p><p>The issue arises when normal testosterone levels do not create the proper ratio of metabolites usually due to deeper metabolic issues. </p><p></p><p>For example I have a daily peak of around 1000ng/dl testosterone as you know; however, my estradiol sits at around 17pg/ml. I also have around 48ng/dl dht level. So I under convert. In order to achieve robust levels of metabolites I directly supplement dht and estradiol while Many men just up their dose of testosterone.</p><p></p><p>The issue is that the ratios are already bad so upping the dose makes them worse possibly until maybe at certain point at which enzymes are maxed out with one metabolite and then the ratio begins to improve with further testosterone administration. </p><p></p><p>I look too muscular to only be on 6.25mg of pure testosterone daily and this would partially explain it. </p><p></p><p>I’m becoming a pretty firm believer in dht:e2 ratio being the most important ratio for overall function. They are much more directly tied to neurosteroid and nervous system function than testosterone. We often conflate many of dht and testosterone’s effects. </p><p></p><p>We need more control of the metabolites as that is the reason the people unknowingly are needing higher amounts of testosterone. Not ar sensitivity issues.</p></blockquote><p></p>
[QUOTE="JA Battle, post: 198765, member: 40068"] I would tend to agree that if one exceeds Supra-physiological amounts of testosterone, that there should be be a concurrent amount of estradiol to balance competitive activation of various receptors. As to the ratios we’ve widely used on this forum including all posted versions is 14-30 (tt/se2 in their respective different lab units). This puts e2 at 107 pg/ml max for a 1500ng/dl t level. The question is not about the e2 level exclusively. But rather, the testosterone dosage as it is the cause of the high e2. Many men experience varied metabolism of testosterone into its respective metabolites. And this I believe is the cause of men using more t than what we believe would be necessary. The larger issue you elude to being TT (testosterone therapy) vs TRT (testosterone replacement therapy). They are certainly two things and we are both in the same camp with respect to this matter. Replacement constitutes maintaining reference range testosterone at all times. The issue arises when normal testosterone levels do not create the proper ratio of metabolites usually due to deeper metabolic issues. For example I have a daily peak of around 1000ng/dl testosterone as you know; however, my estradiol sits at around 17pg/ml. I also have around 48ng/dl dht level. So I under convert. In order to achieve robust levels of metabolites I directly supplement dht and estradiol while Many men just up their dose of testosterone. The issue is that the ratios are already bad so upping the dose makes them worse possibly until maybe at certain point at which enzymes are maxed out with one metabolite and then the ratio begins to improve with further testosterone administration. I look too muscular to only be on 6.25mg of pure testosterone daily and this would partially explain it. I’m becoming a pretty firm believer in dht:e2 ratio being the most important ratio for overall function. They are much more directly tied to neurosteroid and nervous system function than testosterone. We often conflate many of dht and testosterone’s effects. We need more control of the metabolites as that is the reason the people unknowingly are needing higher amounts of testosterone. Not ar sensitivity issues. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Sensitive E2 in the 100’s
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