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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Sensitive E2 in the 100’s
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<blockquote data-quote="Cataceous" data-source="post: 198721" data-attributes="member: 38109"><p>I'd consider it ideal to start all TRT patients with frequent injections—qd/qod—and no hCG. The reason why is to develop a dose-response relationship uncontaminated by endogenous testosterone production. After this hCG use could be encouraged, along with less demanding dosing schedules. In spite of the problems with hCG, many guys will still find using it to be preferable to not using it, and not just because of fertility.</p><p></p><p>My experience with LabCorp's standard immunoassay estradiol test has been good. It is very consistent, in stark contrast to the "sensitive" LC/MS test, which seems to throw out non sequiturs at an alarmingly high rate. When the sensitive test isn't botched the immunoassay result is generally a few percent higher. The shortcomings of the immunoassay tests are their cross-reactivity to things like C-reactive protein and their lack of sensitivity at low hormone levels. On the other hand, the immunoassay tests are pretty idiot-proof, while the LC/MS tests are complex and may require a fair bit of fiddling to work correctly. I'd consider it a red flag for the LC/MS test result to be significantly higher than that of the immunoassay test.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 198721, member: 38109"] I'd consider it ideal to start all TRT patients with frequent injections—qd/qod—and no hCG. The reason why is to develop a dose-response relationship uncontaminated by endogenous testosterone production. After this hCG use could be encouraged, along with less demanding dosing schedules. In spite of the problems with hCG, many guys will still find using it to be preferable to not using it, and not just because of fertility. My experience with LabCorp's standard immunoassay estradiol test has been good. It is very consistent, in stark contrast to the "sensitive" LC/MS test, which seems to throw out non sequiturs at an alarmingly high rate. When the sensitive test isn't botched the immunoassay result is generally a few percent higher. The shortcomings of the immunoassay tests are their cross-reactivity to things like C-reactive protein and their lack of sensitivity at low hormone levels. On the other hand, the immunoassay tests are pretty idiot-proof, while the LC/MS tests are complex and may require a fair bit of fiddling to work correctly. I'd consider it a red flag for the LC/MS test result to be significantly higher than that of the immunoassay test. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Sensitive E2 in the 100’s
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