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General Health & Fitness
Nutrition and Supplements
Sense and nonsense concerning biotin interference in laboratory tests
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<blockquote data-quote="madman" data-source="post: 180694" data-attributes="member: 13851"><p><strong><span style="color: rgb(184, 49, 47)">Table 1. </span>Summary of the different parameters with corresponding platforms, their susceptibility to biotin and an indication of whether they show positive or negative bias [28].</strong></p><p>[ATTACH=full]9925[/ATTACH]</p><p>[ATTACH=full]9926[/ATTACH]</p><p>[ATTACH=full]9927[/ATTACH]</p><p>[ATTACH=full]9928[/ATTACH]</p><p>[ATTACH=full]9929[/ATTACH]</p><p><strong>Parameters in bold are easily influenced <span style="color: rgb(184, 49, 47)">(concentrations < 40 ng/mL)</span>, others are somewhat more resistant <span style="color: rgb(184, 49, 47)">(concentrations from > 40 to 100 ng/mL)</span> <span style="color: rgb(44, 130, 201)">and the parameters in italic are those that will only be affected at concentrations of</span> <span style="color: rgb(44, 130, 201)">more than</span><span style="color: rgb(184, 49, 47)"> 100 ng/mL of biotin.</span> The exact concentrations at which interference occurs is platform dependent. This table was made using the Roche platform as standard to which others were compared. Some known very susceptible parameters <span style="color: rgb(184, 49, 47)">(for example FT3 and FT4) </span>are not represented in bold because the reagent has been adapted and newer generation reagents are already widely used.</strong></p></blockquote><p></p>
[QUOTE="madman, post: 180694, member: 13851"] [B][COLOR=rgb(184, 49, 47)]Table 1. [/COLOR]Summary of the different parameters with corresponding platforms, their susceptibility to biotin and an indication of whether they show positive or negative bias [28].[/B] [ATTACH type="full" alt="Screenshot (1526).png"]9925[/ATTACH] [ATTACH type="full" alt="Screenshot (1527).png"]9926[/ATTACH] [ATTACH type="full" alt="Screenshot (1528).png"]9927[/ATTACH] [ATTACH type="full" alt="Screenshot (1529).png"]9928[/ATTACH] [ATTACH type="full" alt="Screenshot (1530).png"]9929[/ATTACH] [B]Parameters in bold are easily influenced [COLOR=rgb(184, 49, 47)](concentrations < 40 ng/mL)[/COLOR], others are somewhat more resistant [COLOR=rgb(184, 49, 47)](concentrations from > 40 to 100 ng/mL)[/COLOR] [COLOR=rgb(44, 130, 201)]and the parameters in italic are those that will only be affected at concentrations of[/COLOR] [COLOR=rgb(44, 130, 201)]more than[/COLOR][COLOR=rgb(184, 49, 47)] 100 ng/mL of biotin.[/COLOR] The exact concentrations at which interference occurs is platform dependent. This table was made using the Roche platform as standard to which others were compared. Some known very susceptible parameters [COLOR=rgb(184, 49, 47)](for example FT3 and FT4) [/COLOR]are not represented in bold because the reagent has been adapted and newer generation reagents are already widely used.[/B] [/QUOTE]
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General Health & Fitness
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Sense and nonsense concerning biotin interference in laboratory tests
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