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Semaglutide: Preventing/Dealing with Side Effects
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<blockquote data-quote="Pacman" data-source="post: 232926" data-attributes="member: 2450"><p>Hi all!</p><p></p><p>I just received my Semaglutide medicine. I am planning to take it later today for the first time.</p><p></p><p>I am excited about it (due to the fact that I have always had weight issues my entire life) but also very nervous (because I tend to have GI issues easily, usually in the form of bloating/gas/pain/etc unless I am very very careful).</p><p></p><p>The thing is, when they say that a certain percentage of people get GI issues from the drug, they never seem to elaborate on some very important variables that could make a huge difference in the outcome of side effects experienced, even with those same exact people. (That I have seen at least)</p><p></p><p>For example, does the person have GI issues to begin with? Are they making it worse with their eating habits prior (or after) injecting? Were they stuffed with food right before injecting? Are they taking any other drugs/compounds that could impact how the GI is reacting to begin with?</p><p></p><p>My hypothesis is that because it slows GI emptying, having a lot of food in there to begin with could contribute to it. All they say is that people have GI issues, but they don't freaking tell us the circumstances of that!!</p><p></p><p>I have googled recommended food to have and avoid with Semaglutide (mostly found results for recommendations with Ozempic, but same thing), and they seem to give all the same recommendations. For example: <a href="https://www.nicerx.com/blog/ozempic-foods-to-avoid/" target="_blank">What foods to avoid while taking Ozempic - NiceRx</a></p><p></p><p>Everything on that list makes sense to me (for both the foods to avoid and foods to consume), except for high fiber foods, at least in the beginning stages of taking Semaglutide.</p><p></p><p>It does not make sense to me that they would recommend high-fiber foods when starting this medication especially for an obese population that most probably does not typically ingest such foods. High fiber foods could cause severe GI distress if your body is not used to them, and they slow digestion down.</p><p></p><p>In my experience, even without any medications that affect GI distress, introducing a lot of fiber to my diet (which slows digestion), while healthy, did cause me a ton of GI distress in the past, because my body was not used to it.</p><p></p><p>So with a GLP-1 agonist (which <strong>also</strong> slows digestion), wouldn’t that be a double-whammy?</p><p></p><p>So I am thinking it makes more sense to have several very light meals, but also meals LOW IN FIBER and to avoid slow digesting animal proteins since both are slower digesting than other foods, and the Semaglutide itself causes slow digestion to occur.</p><p></p><p>(side note: slow digesting animal proteins would be things like meat, and fast digesting animal proteins would be things like whey or nonfat Greek yogurt)</p><p></p><p>I was considering taking ephedrine to help reduce appetite today but I decided not to since ephedrine itself does sometimes cause stomach burning and uncomfortable sensations in my stomach, and I think it is wiser to control all variables that could potentially cause by themselves GI distress, so I can prevent as much as possible all potential GI distress while giving an objective assessment of how my body reacts to this drug.</p><p></p><p><strong><u>So summed up, my plan</u></strong></p><p></p><p>Light meals today!! Keep stomach as empty as comfortably possible today!</p><p></p><p>Do EVERYTHING to reduce eliminate ANY gastro distress PRIOR to injection:</p><p></p><p>1) No ephedrine!!!! - even though it will help reduce food intake, it also causes stomach pain sometimes, so do NOT take it same day prior to injection! (it also apparently delays gastric emptying, which is exactly what Semaglutide does).</p><p></p><p>2) NO artificial sugars or sugar alcohols today!!</p><p></p><p>3) <strong>LIGHT healthy meals</strong>, on the lower end of fiber. Aiming for <u>400 calories or less</u> per meal. Preferably 200-300 cals per meal if possible.</p><p></p><p>4) <strong>Empty GI track as much as possible</strong> prior to injection. Try to aim for “fasting” as much as possible. Also psyllium husks (which I am already used to taking in moderate amounts).</p><p></p><p>5) For when I do eat, <em>at least for today (and maybe tomorrow)</em>, try to ingest <strong>fast digesting foods</strong>. Do not have a lot of fiber today (not too much at least) as the slow digestion process could by itself cause GI pain. So foods like white bread with egg whites, maybe oatmeal (no sweeteners), white rice, nonfat greek yogurt with berries, whey protein with soy milk, everything bland and as plain as possible.</p><p></p><p>6) No garlic extract (which I take to help with cholesterol) or spicy foods. Everything as bland as possible today!! (and maybe tomorrow too)</p><p></p><p>7) No slow digesting foods.</p><p></p><p>And if I am able to stave off sides this time, I can further test my hypothesis by going directly against my own plan this time, but next time I inject, since I can safely rule out such sides from the same dosage. But I am not sure I will do this, as I am not sure I want to deal with sides in the name of science. haha</p><p></p><p>What are your guys' thoughts on my plan? Have any of you taken similar precautions prior to taking Sumeglatide for the first time and/or prior to increasing the dosage?</p><p></p><p><strong><u>If GI distress DOES occur, here is what I have in my arsenal:</u></strong></p><p></p><p>Pepto Bismol, cannabis, and lots of mint tea. That's it. Hopefully that will suffice.</p></blockquote><p></p>
[QUOTE="Pacman, post: 232926, member: 2450"] Hi all! I just received my Semaglutide medicine. I am planning to take it later today for the first time. I am excited about it (due to the fact that I have always had weight issues my entire life) but also very nervous (because I tend to have GI issues easily, usually in the form of bloating/gas/pain/etc unless I am very very careful). The thing is, when they say that a certain percentage of people get GI issues from the drug, they never seem to elaborate on some very important variables that could make a huge difference in the outcome of side effects experienced, even with those same exact people. (That I have seen at least) For example, does the person have GI issues to begin with? Are they making it worse with their eating habits prior (or after) injecting? Were they stuffed with food right before injecting? Are they taking any other drugs/compounds that could impact how the GI is reacting to begin with? My hypothesis is that because it slows GI emptying, having a lot of food in there to begin with could contribute to it. All they say is that people have GI issues, but they don't freaking tell us the circumstances of that!! I have googled recommended food to have and avoid with Semaglutide (mostly found results for recommendations with Ozempic, but same thing), and they seem to give all the same recommendations. For example: [URL='https://www.nicerx.com/blog/ozempic-foods-to-avoid/']What foods to avoid while taking Ozempic - NiceRx[/URL] Everything on that list makes sense to me (for both the foods to avoid and foods to consume), except for high fiber foods, at least in the beginning stages of taking Semaglutide. It does not make sense to me that they would recommend high-fiber foods when starting this medication especially for an obese population that most probably does not typically ingest such foods. High fiber foods could cause severe GI distress if your body is not used to them, and they slow digestion down. In my experience, even without any medications that affect GI distress, introducing a lot of fiber to my diet (which slows digestion), while healthy, did cause me a ton of GI distress in the past, because my body was not used to it. So with a GLP-1 agonist (which [B]also[/B] slows digestion), wouldn’t that be a double-whammy? So I am thinking it makes more sense to have several very light meals, but also meals LOW IN FIBER and to avoid slow digesting animal proteins since both are slower digesting than other foods, and the Semaglutide itself causes slow digestion to occur. (side note: slow digesting animal proteins would be things like meat, and fast digesting animal proteins would be things like whey or nonfat Greek yogurt) I was considering taking ephedrine to help reduce appetite today but I decided not to since ephedrine itself does sometimes cause stomach burning and uncomfortable sensations in my stomach, and I think it is wiser to control all variables that could potentially cause by themselves GI distress, so I can prevent as much as possible all potential GI distress while giving an objective assessment of how my body reacts to this drug. [B][U]So summed up, my plan[/U][/B] Light meals today!! Keep stomach as empty as comfortably possible today! Do EVERYTHING to reduce eliminate ANY gastro distress PRIOR to injection: 1) No ephedrine!!!! - even though it will help reduce food intake, it also causes stomach pain sometimes, so do NOT take it same day prior to injection! (it also apparently delays gastric emptying, which is exactly what Semaglutide does). 2) NO artificial sugars or sugar alcohols today!! 3) [B]LIGHT healthy meals[/B], on the lower end of fiber. Aiming for [U]400 calories or less[/U] per meal. Preferably 200-300 cals per meal if possible. 4) [B]Empty GI track as much as possible[/B] prior to injection. Try to aim for “fasting” as much as possible. Also psyllium husks (which I am already used to taking in moderate amounts). 5) For when I do eat, [I]at least for today (and maybe tomorrow)[/I], try to ingest [B]fast digesting foods[/B]. Do not have a lot of fiber today (not too much at least) as the slow digestion process could by itself cause GI pain. So foods like white bread with egg whites, maybe oatmeal (no sweeteners), white rice, nonfat greek yogurt with berries, whey protein with soy milk, everything bland and as plain as possible. 6) No garlic extract (which I take to help with cholesterol) or spicy foods. Everything as bland as possible today!! (and maybe tomorrow too) 7) No slow digesting foods. And if I am able to stave off sides this time, I can further test my hypothesis by going directly against my own plan this time, but next time I inject, since I can safely rule out such sides from the same dosage. But I am not sure I will do this, as I am not sure I want to deal with sides in the name of science. haha What are your guys' thoughts on my plan? Have any of you taken similar precautions prior to taking Sumeglatide for the first time and/or prior to increasing the dosage? [B][U]If GI distress DOES occur, here is what I have in my arsenal:[/U][/B] Pepto Bismol, cannabis, and lots of mint tea. That's it. Hopefully that will suffice. [/QUOTE]
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Semaglutide: Preventing/Dealing with Side Effects
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