ExcelMale
Menu
Home
What's new
Latest activity
Forums
New posts
Search forums
What's new
New posts
Latest activity
Videos
Lab Tests
Doctor Finder
Buy Books
About Us
Men’s Health Coaching
Log in
Register
What's new
Search
Search
Search titles only
By:
New posts
Search forums
Menu
Log in
Register
Navigation
Install the app
Install
More options
Contact us
Close Menu
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
Second test confirmed my E2 is extremely low... not on any AI. HELP!
JavaScript is disabled. For a better experience, please enable JavaScript in your browser before proceeding.
You are using an out of date browser. It may not display this or other websites correctly.
You should upgrade or use an
alternative browser
.
Reply to thread
Message
<blockquote data-quote="Formula364" data-source="post: 62104" data-attributes="member: 13948"><p>T4 only is a pretty flaccid response (and common) from you Dr. It doesn't guarantee increased T3. Don't drive your DHEA levels too high.</p><p>Your SHBG is fairly low - a few points of interest:</p><p></p><p>"The most common cause of low SHBG is excessive insulin - i.e. insulin resistance. Insulin resistance in turn leads to a cascade of events which results other hormone imbalances such as low testosterone production, suboptimal thyroid hormone activity, adrenal fatigue, etc.</p><p></p><p>Factors which together in a balance determine SHBG are:</p><p>1. Anabolic hormones generally reduce SHBG. These include testosterone, DHEA, insulin, DHT, and growth hormone.</p><p>2. Thyroid hormone, Estrogens, and Progesterone (by increasing estrogen receptors/sensitivity), increase SHBG."</p><p></p><p>"Even with low SHBG - which is difficult to correct since it depends on the balance of so many hormones - when the other hormones and neurotransmitters are optimized, sex drive and the ability to have an erection can often return.</p><p></p><p><strong>Increases SHBG:</strong></p><p>Estrogens (particularly Estradiol)</p><p>Progesterone (by increasing Estrogen receptors)</p><p>Thyroid Hormone (particularly Hyperthyroidism)</p><p>Liver Disease</p><p>Anorexia, Starvation</p><p>Hypoglycemia (low insulin)</p><p></p><p><strong>Reduces SHBG:</strong></p><p>Insulin (and insulin resistance)</p><p>Testosterone</p><p>Growth Hormone</p><p>DHEA</p><p>Other Androgens</p><p>Obesity</p><p>Hypothyroidism</p><p>Excessive Cortisol (Cushing's Syndrome or Disease)</p><p>Progestins (such as by blocking progesterone's effects)</p><p></p><p>The primary purpose of a binding protein such as SHBG is to prolong the life of testosterone in the body. Otherwise, with a half-life of 10-100 minutes - testosterone would be almost totally eliminated from the body within 50 minutes to 8.3 hours without constant production or frequent application of testosterone." <u>You need to investigate more frequent injections until you raise SBHG.</u></p><p></p><p>"The quickest way to increase SHBG is to treat a person with T3 (Cytomel) or to a lesser extent Armour Thyroid, when optimizing thyroid hormone signaling. This increases SHBG production from the liver. Optimizing thyroid signaling first is important to set the stage for subsequent testosterone treatment. Doing so helps correct low SHBG.</p><p></p><p>Low SHBG is one of many reasons testosterone levels are so low in diabetes type 2. When SHBG is low due to insulin resistance/diabetes type 2 and high insulin level, treatment with testosterone helps reduce insulin resistance. Over several months time, SHBG self-corrects as other metabolic improvements with testosterone treatment occur such as loss of belly fat. Of course, in the presence of diabetes type 2, one of the first things to do is to optimize thyroid hormone and treat the insulin resistance with medications such as Metformin or Actos. This would help improve SHBG and would set the stage for testosterone treatment, minimizing problems that can occur with testosterone treatment - such as anxiety, irritability, fatigue, excessive estrogen, etc."</p></blockquote><p></p>
[QUOTE="Formula364, post: 62104, member: 13948"] T4 only is a pretty flaccid response (and common) from you Dr. It doesn't guarantee increased T3. Don't drive your DHEA levels too high. Your SHBG is fairly low - a few points of interest: "The most common cause of low SHBG is excessive insulin - i.e. insulin resistance. Insulin resistance in turn leads to a cascade of events which results other hormone imbalances such as low testosterone production, suboptimal thyroid hormone activity, adrenal fatigue, etc. Factors which together in a balance determine SHBG are: 1. Anabolic hormones generally reduce SHBG. These include testosterone, DHEA, insulin, DHT, and growth hormone. 2. Thyroid hormone, Estrogens, and Progesterone (by increasing estrogen receptors/sensitivity), increase SHBG." "Even with low SHBG - which is difficult to correct since it depends on the balance of so many hormones - when the other hormones and neurotransmitters are optimized, sex drive and the ability to have an erection can often return. [B]Increases SHBG:[/B] Estrogens (particularly Estradiol) Progesterone (by increasing Estrogen receptors) Thyroid Hormone (particularly Hyperthyroidism) Liver Disease Anorexia, Starvation Hypoglycemia (low insulin) [B]Reduces SHBG:[/B] Insulin (and insulin resistance) Testosterone Growth Hormone DHEA Other Androgens Obesity Hypothyroidism Excessive Cortisol (Cushing's Syndrome or Disease) Progestins (such as by blocking progesterone's effects) The primary purpose of a binding protein such as SHBG is to prolong the life of testosterone in the body. Otherwise, with a half-life of 10-100 minutes - testosterone would be almost totally eliminated from the body within 50 minutes to 8.3 hours without constant production or frequent application of testosterone." [U]You need to investigate more frequent injections until you raise SBHG.[/U] "The quickest way to increase SHBG is to treat a person with T3 (Cytomel) or to a lesser extent Armour Thyroid, when optimizing thyroid hormone signaling. This increases SHBG production from the liver. Optimizing thyroid signaling first is important to set the stage for subsequent testosterone treatment. Doing so helps correct low SHBG. Low SHBG is one of many reasons testosterone levels are so low in diabetes type 2. When SHBG is low due to insulin resistance/diabetes type 2 and high insulin level, treatment with testosterone helps reduce insulin resistance. Over several months time, SHBG self-corrects as other metabolic improvements with testosterone treatment occur such as loss of belly fat. Of course, in the presence of diabetes type 2, one of the first things to do is to optimize thyroid hormone and treat the insulin resistance with medications such as Metformin or Actos. This would help improve SHBG and would set the stage for testosterone treatment, minimizing problems that can occur with testosterone treatment - such as anxiety, irritability, fatigue, excessive estrogen, etc." [/QUOTE]
Insert quotes…
Verification
Post reply
Share this page
Facebook
Twitter
Reddit
Pinterest
Tumblr
WhatsApp
Email
Share
Link
Sponsors
Forums
Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
Second test confirmed my E2 is extremely low... not on any AI. HELP!
This site uses cookies to help personalise content, tailor your experience and to keep you logged in if you register.
By continuing to use this site, you are consenting to our use of cookies.
Accept
Learn more…
Top