I have not noticed any E2 changes nor any issues w/ SHBG. Of course I have pretty high SHBG. So if it dropped any I wouldn't complain.
As far as dosage. I used to apply 2 clicks daily, some on my thigh and some on my scrotum. lately I have been decreasing my dose of cypionate and cream. So now I do 1-1.5 clicks daily. I change where I apply the cream based upon libido requirements. If I want to ramp my sex drive up, I apply relatively more to my scrotum. Cream is a very handy tool to use in this way. I have a lot of control over my libido this way.
