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When I did it I was instructed to apply 2 clicks (100 mg) twice a day, which I believe is the same dosage Dr Nichols starts people out on. My DHT shot WAY up and I didn't tolerate it well (I have pre existing anxiety and seem to be hypersensitive to any kind of stimulating substance).  I lowered it to 100 mg and eventually 50 mg a day.  I will say that in the area of energy and libido I noticed an improvement over injections.  However, I could never get over the overstimulated feeling and was always red (almost purple) in the face, neck and chest and could "feel" my heart beating all the time.  If you're not having any of these issues with it I would just start with 50 mg a day and titrate up as necessary.  I really think this method could be the way to go for alot of guys if they tolerate it.  FWIW I also think most guys will be overdosing on 200 mg a day.  Good luck.