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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Scientists report that enzyme that alters testosterone to estrogen has big impact in healthy brain
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<blockquote data-quote="Nelson Vergel" data-source="post: 18290" data-attributes="member: 3"><p>Another reason not to mess with your aromatase activity (Most of you know my opinion about how many men on TRT are overdosing anastrozole when most do not even need it)</p><p></p><p></p><p>"An enzyme that converts testosterone to estrogen appears to have significant impact in a healthy and injured brain, scientists report.</p><p></p><p></p><p>There's mounting evidence that in the healthy brain, aromatase and the estrogen it enables neurons to produce, helps keep our brains and us nimble. Now scientists are learning that with injury, aromatase and estrogen expression seem to shift to cells in the brain called astrocytes, aiding their support and nurturing of now-stressed neurons, said Dr. Darrell Brann, Regents' Professor and Vice Chairman of the Department of Neuroscience and Regenerative Medicine at the Medical College of Georgia at Georgia Regents University.</p><p></p><p></p><p>Several studies, including those in Brann's lab, have shown this primary shift in aromatase/estrogen expression from neurons to astrocytes following injury. In Brann's case, the studies have been in the hippocampus, a center of learning, memory, and emotions. When he used a drug to reduce astrocyte's aromatase expression in that region, increased inflammation and brain damage resulted.</p><p></p><p></p><p>Even in culture, neurons will connect and communicate, but when scientists add an aromatase inhibitor to the mix, connectivity is interrupted. Some of the first in vivo studies in zebra finches showed that aromatase levels increased following a brain injury, which also supports a protective role for the protein. More brain damage results when aromatase inhibitors are given. "There seemed to be more inflammation," Brann said.</p><p></p><p><a href="http://www.news-medical.net/news/20150505/Scientists-report-that-enzyme-that-alters-testosterone-to-estrogen-has-big-impact-in-healthy-injured-brain.aspx" target="_blank">http://www.news-medical.net/news/20150505/Scientists-report-that-enzyme-that-alters-testosterone-to-estrogen-has-big-impact-in-healthy-injured-brain.aspx</a></p></blockquote><p></p>
[QUOTE="Nelson Vergel, post: 18290, member: 3"] Another reason not to mess with your aromatase activity (Most of you know my opinion about how many men on TRT are overdosing anastrozole when most do not even need it) "An enzyme that converts testosterone to estrogen appears to have significant impact in a healthy and injured brain, scientists report. There's mounting evidence that in the healthy brain, aromatase and the estrogen it enables neurons to produce, helps keep our brains and us nimble. Now scientists are learning that with injury, aromatase and estrogen expression seem to shift to cells in the brain called astrocytes, aiding their support and nurturing of now-stressed neurons, said Dr. Darrell Brann, Regents' Professor and Vice Chairman of the Department of Neuroscience and Regenerative Medicine at the Medical College of Georgia at Georgia Regents University. Several studies, including those in Brann's lab, have shown this primary shift in aromatase/estrogen expression from neurons to astrocytes following injury. In Brann's case, the studies have been in the hippocampus, a center of learning, memory, and emotions. When he used a drug to reduce astrocyte's aromatase expression in that region, increased inflammation and brain damage resulted. Even in culture, neurons will connect and communicate, but when scientists add an aromatase inhibitor to the mix, connectivity is interrupted. Some of the first in vivo studies in zebra finches showed that aromatase levels increased following a brain injury, which also supports a protective role for the protein. More brain damage results when aromatase inhibitors are given. "There seemed to be more inflammation," Brann said. [url]http://www.news-medical.net/news/20150505/Scientists-report-that-enzyme-that-alters-testosterone-to-estrogen-has-big-impact-in-healthy-injured-brain.aspx[/url] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Scientists report that enzyme that alters testosterone to estrogen has big impact in healthy brain
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