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I guess my issue with this debate is that there is no evidence that long term elevated estrogen in men is harmful and there is no evidence that long term use of very low dose anastrazole is harmful. So the only thing we can do at this point is use common sense. Since estrogens are hormones and most doctors think hormones do have a safe and healthy range, it stands to reason that long term health can be negatively affected by any hormone imbalance.