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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Scientists report that enzyme that alters testosterone to estrogen has big impact in healthy brain
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<blockquote data-quote="Nelson Vergel" data-source="post: 126766" data-attributes="member: 3"><p>I am so glad that we have a PhD on ExcelMale that can help us digest these data!</p><p></p><p>"Aromatase catalyzes the last step in estrogen biosynthesis. Brain aromatase is involved in diverse neurophysiological and behavioral functions including sexual behavior, aggression, cognition, and neuroprotection. Using positron emission tomography (PET) with the radiolabeled aromatase inhibitor [ N ‐methyl‐ 11 C]vorozole, we characterized the tracer distribution and kinetics in the living human brain. Six young, healthy subjects, three men and three women, were administered the radiotracer alone on two separate occasions. Women were scanned in distinct phases of the menstrual cycle. Specificity was confirmed by pretreatment with a pharmacological (2.5 mg) dose of the aromatase inhibitor letrozole. PET data were acquired over a 90‐min period and regions of interest placed over selected brain regions. Brain and plasma time-activity curves, corrected for metabolites, were used to derive kinetic parameters. Distribution volume (V T ) values in both men and women followed the following rank order: thalamus > amygdala = preoptic area > medulla (inferior olive) > accumbens, pons, occipital and temporal cortex, putamen, cerebellum, and white matter. Pretreatment with letrozole reduced V T in all regions, though the size of the reduction was region‐dependent, ranging from ∼70% blocking in thalamus and preoptic area to ∼10% in the cerebellum. The high levels of aromatase in thalamus and medulla (inferior olive) appear to be unique to humans. These studies set the stage for the noninvasive assessment of aromatase involvement in various physiological and pathological processes affecting the human brain". Synapse 64:801–807, 2010.</p><p></p><p></p><p>Unique distribution of aromatase in the human brain: In vivo studies with PET and [N‐methyl‐11C]vorozole</p><p>by Biegon, Anat; Kim, Sung Won; Alexoff, David L;</p><p>Synapse, 11/2010, Volume 64, Issue 11</p><p></p><p>Paper attached</p></blockquote><p></p>
[QUOTE="Nelson Vergel, post: 126766, member: 3"] I am so glad that we have a PhD on ExcelMale that can help us digest these data! "Aromatase catalyzes the last step in estrogen biosynthesis. Brain aromatase is involved in diverse neurophysiological and behavioral functions including sexual behavior, aggression, cognition, and neuroprotection. Using positron emission tomography (PET) with the radiolabeled aromatase inhibitor [ N ‐methyl‐ 11 C]vorozole, we characterized the tracer distribution and kinetics in the living human brain. Six young, healthy subjects, three men and three women, were administered the radiotracer alone on two separate occasions. Women were scanned in distinct phases of the menstrual cycle. Specificity was confirmed by pretreatment with a pharmacological (2.5 mg) dose of the aromatase inhibitor letrozole. PET data were acquired over a 90‐min period and regions of interest placed over selected brain regions. Brain and plasma time-activity curves, corrected for metabolites, were used to derive kinetic parameters. Distribution volume (V T ) values in both men and women followed the following rank order: thalamus > amygdala = preoptic area > medulla (inferior olive) > accumbens, pons, occipital and temporal cortex, putamen, cerebellum, and white matter. Pretreatment with letrozole reduced V T in all regions, though the size of the reduction was region‐dependent, ranging from ∼70% blocking in thalamus and preoptic area to ∼10% in the cerebellum. The high levels of aromatase in thalamus and medulla (inferior olive) appear to be unique to humans. These studies set the stage for the noninvasive assessment of aromatase involvement in various physiological and pathological processes affecting the human brain". Synapse 64:801–807, 2010. Unique distribution of aromatase in the human brain: In vivo studies with PET and [N‐methyl‐11C]vorozole by Biegon, Anat; Kim, Sung Won; Alexoff, David L; Synapse, 11/2010, Volume 64, Issue 11 Paper attached [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Scientists report that enzyme that alters testosterone to estrogen has big impact in healthy brain
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