ExcelMale
Menu
Home
What's new
Latest activity
Forums
New posts
Search forums
What's new
New posts
Latest activity
Videos
Lab Tests
Doctor Finder
Buy Books
About Us
Men’s Health Coaching
Log in
Register
What's new
Search
Search
Search titles only
By:
New posts
Search forums
Menu
Log in
Register
Navigation
Install the app
Install
More options
Contact us
Close Menu
Forums
Clinical Use of Anabolics and Hormones
Clinical Use of Anabolics and Hormones
SARMs versus AAS: Different Side Effects?
JavaScript is disabled. For a better experience, please enable JavaScript in your browser before proceeding.
You are using an out of date browser. It may not display this or other websites correctly.
You should upgrade or use an
alternative browser
.
Reply to thread
Message
<blockquote data-quote="madman" data-source="post: 190774" data-attributes="member: 13851"><p><strong>Figure 1. <span style="color: rgb(184, 49, 47)">A depiction of the differences potentially defining AR-binding between androgens </span><span style="color: rgb(0, 0, 0)">(testosterone & DHT)</span><span style="color: rgb(184, 49, 47)"> compared with non-steroidal SARMs.</span><span style="color: rgb(44, 130, 201)"> In brief, SARMs ideally denote beneficial anabolic actions in androgen-responsive tissues such as skeletal muscle and bone, without unwanted androgenic side effects. <u>They do not undergo conversion to DHT or estradiol, which partially mediates a lack of SARM-induced androgenic impact</u>.</span> <span style="color: rgb(26, 188, 156)">The SARM mechanism of action is far from elucidated, but potentially may be sourced in 5α-reductase or aromatase modulation, as well as a potential inability for N/C interaction between the ligand-independent NH2-terminal transactivation domain </span><span style="color: rgb(0, 0, 0)">(AF-1)</span><span style="color: rgb(26, 188, 156)"> located in the DBD and the ligand-dependent carboxy-terminal transactivation domain </span><span style="color: rgb(0, 0, 0)">(AF-2)</span><span style="color: rgb(26, 188, 156)"> located in the LBD. Through this incomplete interaction that is typically deemed necessary for full AR agonist activation, SARMs may also impact AR DBD topology and affect the ability of the transcriptional binding complex to recognize specific DNA sequences. Incomplete N/C interaction ostensibly alters coregulator recruitment, indicating that SARMs selectively inducing different coactivators and corepressors, as well as recruiting them in differential magnitudes relative to androgens</span> [21, 25, 34, 36, 40, 50, 64, 65].</strong></p><p>[ATTACH=full]11627[/ATTACH]</p><p><strong><span style="color: rgb(26, 188, 156)">ARE </span>= androgen response elements; <span style="color: rgb(26, 188, 156)">AF-1</span> = activation function 1; <span style="color: rgb(26, 188, 156)">AF-2</span> = activation function 2; <span style="color: rgb(26, 188, 156)">AR</span> = androgen receptor;<span style="color: rgb(26, 188, 156)"> DBD</span> = DNA-binding domain; <span style="color: rgb(26, 188, 156)">ECF</span> = extracellular fluid;<span style="color: rgb(26, 188, 156)"> ER </span>= estrogen receptor <span style="color: rgb(26, 188, 156)">HSP</span> = heat shock proteins <span style="color: rgb(26, 188, 156)">ICF</span> = intracellular fluid; <span style="color: rgb(26, 188, 156)">LBD</span> = ligand-binding domain; <span style="color: rgb(26, 188, 156)">SARM</span> = selective estrogen receptor modulator </strong></p></blockquote><p></p>
[QUOTE="madman, post: 190774, member: 13851"] [B]Figure 1. [COLOR=rgb(184, 49, 47)]A depiction of the differences potentially defining AR-binding between androgens [/COLOR][COLOR=rgb(0, 0, 0)](testosterone & DHT)[/COLOR][COLOR=rgb(184, 49, 47)] compared with non-steroidal SARMs.[/COLOR][COLOR=rgb(44, 130, 201)] In brief, SARMs ideally denote beneficial anabolic actions in androgen-responsive tissues such as skeletal muscle and bone, without unwanted androgenic side effects. [U]They do not undergo conversion to DHT or estradiol, which partially mediates a lack of SARM-induced androgenic impact[/U].[/COLOR] [COLOR=rgb(26, 188, 156)]The SARM mechanism of action is far from elucidated, but potentially may be sourced in 5α-reductase or aromatase modulation, as well as a potential inability for N/C interaction between the ligand-independent NH2-terminal transactivation domain [/COLOR][COLOR=rgb(0, 0, 0)](AF-1)[/COLOR][COLOR=rgb(26, 188, 156)] located in the DBD and the ligand-dependent carboxy-terminal transactivation domain [/COLOR][COLOR=rgb(0, 0, 0)](AF-2)[/COLOR][COLOR=rgb(26, 188, 156)] located in the LBD. Through this incomplete interaction that is typically deemed necessary for full AR agonist activation, SARMs may also impact AR DBD topology and affect the ability of the transcriptional binding complex to recognize specific DNA sequences. Incomplete N/C interaction ostensibly alters coregulator recruitment, indicating that SARMs selectively inducing different coactivators and corepressors, as well as recruiting them in differential magnitudes relative to androgens[/COLOR] [21, 25, 34, 36, 40, 50, 64, 65].[/B] [ATTACH type="full" alt="Screenshot (2573).png"]11627[/ATTACH] [B][COLOR=rgb(26, 188, 156)]ARE [/COLOR]= androgen response elements; [COLOR=rgb(26, 188, 156)]AF-1[/COLOR] = activation function 1; [COLOR=rgb(26, 188, 156)]AF-2[/COLOR] = activation function 2; [COLOR=rgb(26, 188, 156)]AR[/COLOR] = androgen receptor;[COLOR=rgb(26, 188, 156)] DBD[/COLOR] = DNA-binding domain; [COLOR=rgb(26, 188, 156)]ECF[/COLOR] = extracellular fluid;[COLOR=rgb(26, 188, 156)] ER [/COLOR]= estrogen receptor [COLOR=rgb(26, 188, 156)]HSP[/COLOR] = heat shock proteins [COLOR=rgb(26, 188, 156)]ICF[/COLOR] = intracellular fluid; [COLOR=rgb(26, 188, 156)]LBD[/COLOR] = ligand-binding domain; [COLOR=rgb(26, 188, 156)]SARM[/COLOR] = selective estrogen receptor modulator [/B] [/QUOTE]
Insert quotes…
Verification
Post reply
Share this page
Facebook
Twitter
Reddit
Pinterest
Tumblr
WhatsApp
Email
Share
Link
Sponsors
Forums
Clinical Use of Anabolics and Hormones
Clinical Use of Anabolics and Hormones
SARMs versus AAS: Different Side Effects?
This site uses cookies to help personalise content, tailor your experience and to keep you logged in if you register.
By continuing to use this site, you are consenting to our use of cookies.
Accept
Learn more…
Top