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General Health & Fitness
Nutrition and Supplements
SARM use and related adverse events including drug‑induced liver injury
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<blockquote data-quote="madman" data-source="post: 274508" data-attributes="member: 13851"><p><em><strong>*SARMs act as ligands by diffusing into the cell and binding to the androgen receptor in the cytoplasm.</strong> <strong>This creates a receptor–ligand complex that translocates to the nucleus where it binds to DNA and acts as a transcriptional regulator of androgen genes response. <u>Unlike natural ligands of this receptor, SARMs have a tissue-selective effect, which gives them a significant advantage over other steroidal anabolic substances</u> [1]</strong></em></p><p><em><strong>.</strong></em></p><p><em><strong>*<em><strong>SARM agonists, which have shown the potential to stimulate muscle growth (anabolic effect) and improve bone reconstruction, are undergoing clinical trials and <u>have not yet been approved by the Food and Drug Administration (FDA) or European Medicine Agency (EMA) for pharmacotherapy</u> [2].</strong></em></strong></em></p><p><em><strong></strong></em></p><p><em><strong>*<em><strong><u>current knowledge of the toxicity mechanisms of SARMs is insufficient</u>. <u>Uncontrolled dosing and/or combining several SARM compounds in one product may lead to AEs related to liver damage and affect lipid metabolism disorders</u>. Withdrawal of the substance often results in liver recovery, but the actual number of SARM users remains unclear. </strong></em></strong></em></p><p><em><strong><em><strong></strong></em></strong></em></p><p><em><strong><em><strong>*Analytical tests have confirmed many discrepancies in both <u>quantity and quality analysis, indicating a very low quality of SARM products available on the market</u>. <u>Labels often do not provide accurate information for consumers, and cases of counterfeit and fake manipulation among ingredients and declared doses have been confirmed</u>.</strong></em></strong></em></p></blockquote><p></p>
[QUOTE="madman, post: 274508, member: 13851"] [I][B]*SARMs act as ligands by diffusing into the cell and binding to the androgen receptor in the cytoplasm.[/B] [B]This creates a receptor–ligand complex that translocates to the nucleus where it binds to DNA and acts as a transcriptional regulator of androgen genes response. [U]Unlike natural ligands of this receptor, SARMs have a tissue-selective effect, which gives them a significant advantage over other steroidal anabolic substances[/U] [1] . *[I][B]SARM agonists, which have shown the potential to stimulate muscle growth (anabolic effect) and improve bone reconstruction, are undergoing clinical trials and [U]have not yet been approved by the Food and Drug Administration (FDA) or European Medicine Agency (EMA) for pharmacotherapy[/U] [2].[/B][/I] *[I][B][U]current knowledge of the toxicity mechanisms of SARMs is insufficient[/U]. [U]Uncontrolled dosing and/or combining several SARM compounds in one product may lead to AEs related to liver damage and affect lipid metabolism disorders[/U]. Withdrawal of the substance often results in liver recovery, but the actual number of SARM users remains unclear. *Analytical tests have confirmed many discrepancies in both [U]quantity and quality analysis, indicating a very low quality of SARM products available on the market[/U]. [U]Labels often do not provide accurate information for consumers, and cases of counterfeit and fake manipulation among ingredients and declared doses have been confirmed[/U].[/B][/I][/B][/I] [/QUOTE]
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General Health & Fitness
Nutrition and Supplements
SARM use and related adverse events including drug‑induced liver injury
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