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SAM-E: Safe to take if on Zoloft?
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<blockquote data-quote="Nelson Vergel" data-source="post: 6802" data-attributes="member: 3"><p><strong>SAMe Improves Fatigue, Depression, and Protects the Liver</strong></p><p></p><p>Routinely prescribed in Europe for nearly 30 y, SAMe has gained popularity in the United States since its release as an over-the-counter dietary supplement in 1998&#8211;1999. Given its range of activity, SAMe has been proposed as a potential treatment for many medical conditions, particularly major depression (<a href="http://ajcn.nutrition.org/content/76/5/1158S.full#ref-10" target="_blank">10</a>). Marketed as an agent for improving mood and emotional well-being, SAMe has been featured in the national media and the popular press and has steadily attracted the attention of patients and clinicians.</p><p></p><p>SAMe is synthesized from the amino acid L-methionine through a metabolic pathway called the one-carbon cycle, which relies, in part, on <strong>adequate concentrations of the vitamins folate and B-12 </strong>(Figure 1<a href="http://ajcn.nutrition.org/content/76/5/1158S.full#F1" target="_blank">&#8657;</a>) (<a href="http://ajcn.nutrition.org/content/76/5/1158S.full#ref-10" target="_blank">10</a>, <a href="http://ajcn.nutrition.org/content/76/5/1158S.full#ref-11" target="_blank">11</a>). Deficiencies of both of these vitamins have also been linked to depression. For example, between 10% and 30% of depressed patients may have low folate concentrations, and these patients appear to respond less well to antidepressants (<a href="http://ajcn.nutrition.org/content/76/5/1158S.full#ref-12" target="_blank">12</a>). Vitamin B-12 is converted to methylcobalamin, which is also involved in the synthesis of the various central nervous system neurotransmitters. Vitamin B-12 deficiency may result in an earlier age of onset of depression (<a href="http://ajcn.nutrition.org/content/76/5/1158S.full#ref-13" target="_blank">13</a>). The common mediator of this effect may be reduced SAMe. Correction of folate and vitamin B-12 deficiencies may alleviate depressive symptoms and augment the response to antidepressant therapy, perhaps because of the resultant increase in SAMe concentrations.</p><p></p><p>Source: <a href="http://ajcn.nutrition.org/content/76/5/1158S.full" target="_blank">http://ajcn.nutrition.org/content/76/5/1158S.full</a></p><p></p><p>Buy SAMe: <a href="http://www.amazon.com/Jarrow-Formulas-SAM--400-Count/dp/B0013OSJU0/ref=sr_1_4?ie=UTF8&qid=1395429120&sr=8-4&keywords=same+400mg" target="_blank">http://www.amazon.com/Jarrow-Formulas-SAM--400-Count/dp/B0013OSJU0/ref=sr_1_4?ie=UTF8&qid=1395429120&sr=8-4&keywords=same+400mg</a></p></blockquote><p></p>
[QUOTE="Nelson Vergel, post: 6802, member: 3"] [b]SAMe Improves Fatigue, Depression, and Protects the Liver[/b] Routinely prescribed in Europe for nearly 30 y, SAMe has gained popularity in the United States since its release as an over-the-counter dietary supplement in 1998–1999. Given its range of activity, SAMe has been proposed as a potential treatment for many medical conditions, particularly major depression ([URL="http://ajcn.nutrition.org/content/76/5/1158S.full#ref-10"]10[/URL]). Marketed as an agent for improving mood and emotional well-being, SAMe has been featured in the national media and the popular press and has steadily attracted the attention of patients and clinicians. SAMe is synthesized from the amino acid L-methionine through a metabolic pathway called the one-carbon cycle, which relies, in part, on [B]adequate concentrations of the vitamins folate and B-12 [/B](Figure 1[URL="http://ajcn.nutrition.org/content/76/5/1158S.full#F1"]⇑[/URL]) ([URL="http://ajcn.nutrition.org/content/76/5/1158S.full#ref-10"]10[/URL], [URL="http://ajcn.nutrition.org/content/76/5/1158S.full#ref-11"]11[/URL]). Deficiencies of both of these vitamins have also been linked to depression. For example, between 10% and 30% of depressed patients may have low folate concentrations, and these patients appear to respond less well to antidepressants ([URL="http://ajcn.nutrition.org/content/76/5/1158S.full#ref-12"]12[/URL]). Vitamin B-12 is converted to methylcobalamin, which is also involved in the synthesis of the various central nervous system neurotransmitters. Vitamin B-12 deficiency may result in an earlier age of onset of depression ([URL="http://ajcn.nutrition.org/content/76/5/1158S.full#ref-13"]13[/URL]). The common mediator of this effect may be reduced SAMe. Correction of folate and vitamin B-12 deficiencies may alleviate depressive symptoms and augment the response to antidepressant therapy, perhaps because of the resultant increase in SAMe concentrations. Source: [URL]http://ajcn.nutrition.org/content/76/5/1158S.full[/URL] Buy SAMe: [url]http://www.amazon.com/Jarrow-Formulas-SAM--400-Count/dp/B0013OSJU0/ref=sr_1_4?ie=UTF8&qid=1395429120&sr=8-4&keywords=same+400mg[/url] [/QUOTE]
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SAM-E: Safe to take if on Zoloft?
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