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Message: <blockquote data-quote="Vince" data-source="post: 149825" data-attributes="member: 843">When on the T4/T3 combination, just like with Natural Desiccated Thyroid, patients have noted that optimal equals a free T3 towards the top part of the range, and a free T4 right around mid-range. Why only around mid-range for free T4? Because over time, patients started to see an increase in RT3, the inactive hormone, if they went above mid-range or higher.<a href="https://stopthethyroidmadness.com/dosing-with-t3-only/" target="_blank">Dosing with T3-only (or with low-dose NDT, or the combination of T4/T3) - Stop The Thyroid Madness</a></blockquote>