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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Role of E2 in Men and Its Management
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<blockquote data-quote="bullseye55" data-source="post: 242778" data-attributes="member: 39890"><p>Hello Nelson, it is good to have Discounted Labs serving Kansas residents again. I really appreciate you making it happen. You run one very responsive company which is becoming more of a rarity. Now on to the topics of estrogens. Somewhere on the site is some great work published by Dr. Glueck and others as it relates to increased blood clotting potential and testosterone therapy. I believe he was a strong proponent of men getting a hypercoag lab panel before starting trt to identify underlying potential increased risks of adding trt. After my personal experience with a DVT and Pulmonary Emboli while on trt I would agree with him 100%. What you don't know can hurt or kill you. I had to push for one of these panels after the fact. Results showed I had elevated Factor VIII and elevated homocysteine. The homocysteine is usually easy to fix with folic acid (or some cases methylfolate due to MTHFR deficiency). Case studies say lowering it doesn't lower risk but I say why doesn't it? Good to get it fixed anyway. The Factor VIII is just something I will have to live with. My point here is if you have some of these clotting disorders they may be activated by higher estrogens which is a product of testosterone metabolism. Young women taking estrogen based oral contraceptives are at risk if they have these same undiagnosed hypercoag issues. I believe if you have any of these conditions you need to be conservative in your allowable estrogen levels (E2). I don't think it is as simple as a ratio between T&E Both of my E2 levels at the times of these events were 39/39.5. Total T was 932/1926. There is nothing in common between these ratios just the estrogen levels. I had used anastrozole in small doses of 0.1 to 0.125mg every 3rd day and that kept me in the 20-30 range which Life Extension attributes to the lowest all cause mortality, but that was not the case at the time of these incidents. The takeaway is have the hypercoag panel done, for a few hundred dollars you can get a lot of peace of mind and also identify what risk factors you need to manage and if the benefit to risk ratio is acceptable to you. Off all trt my levels dropped to T/FT 189/2.4. After nine months of no trt and a plethora of symptoms that just wouldn't resolve I told my physician I was going back on it with what I had on hand to see if that resolved my symptoms. He was in agreement. Didn't take long to feel the difference. His requirement was I needed to remain on Xarelto which is almost a requirement for people who experience repeat clotting events. Personally I regard managing the estrogens consistently as a better insurance policy. But they are compatible and just in case the cause of the DVT and PE are not estrogen related it may provide some level of protection against the unknown. The new regimen will be based around subcutaneous Test Cyp. I thank this site for pointing me in that direction.</p></blockquote><p></p>
[QUOTE="bullseye55, post: 242778, member: 39890"] Hello Nelson, it is good to have Discounted Labs serving Kansas residents again. I really appreciate you making it happen. You run one very responsive company which is becoming more of a rarity. Now on to the topics of estrogens. Somewhere on the site is some great work published by Dr. Glueck and others as it relates to increased blood clotting potential and testosterone therapy. I believe he was a strong proponent of men getting a hypercoag lab panel before starting trt to identify underlying potential increased risks of adding trt. After my personal experience with a DVT and Pulmonary Emboli while on trt I would agree with him 100%. What you don't know can hurt or kill you. I had to push for one of these panels after the fact. Results showed I had elevated Factor VIII and elevated homocysteine. The homocysteine is usually easy to fix with folic acid (or some cases methylfolate due to MTHFR deficiency). Case studies say lowering it doesn't lower risk but I say why doesn't it? Good to get it fixed anyway. The Factor VIII is just something I will have to live with. My point here is if you have some of these clotting disorders they may be activated by higher estrogens which is a product of testosterone metabolism. Young women taking estrogen based oral contraceptives are at risk if they have these same undiagnosed hypercoag issues. I believe if you have any of these conditions you need to be conservative in your allowable estrogen levels (E2). I don't think it is as simple as a ratio between T&E Both of my E2 levels at the times of these events were 39/39.5. Total T was 932/1926. There is nothing in common between these ratios just the estrogen levels. I had used anastrozole in small doses of 0.1 to 0.125mg every 3rd day and that kept me in the 20-30 range which Life Extension attributes to the lowest all cause mortality, but that was not the case at the time of these incidents. The takeaway is have the hypercoag panel done, for a few hundred dollars you can get a lot of peace of mind and also identify what risk factors you need to manage and if the benefit to risk ratio is acceptable to you. Off all trt my levels dropped to T/FT 189/2.4. After nine months of no trt and a plethora of symptoms that just wouldn't resolve I told my physician I was going back on it with what I had on hand to see if that resolved my symptoms. He was in agreement. Didn't take long to feel the difference. His requirement was I needed to remain on Xarelto which is almost a requirement for people who experience repeat clotting events. Personally I regard managing the estrogens consistently as a better insurance policy. But they are compatible and just in case the cause of the DVT and PE are not estrogen related it may provide some level of protection against the unknown. The new regimen will be based around subcutaneous Test Cyp. I thank this site for pointing me in that direction. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Role of E2 in Men and Its Management
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