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General Health & Fitness
Nutrition and Supplements
Resveratrol: No Impact on Metabolic Syndrome, Negatively Impacts Certain Markers
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<blockquote data-quote="CoastWatcher" data-source="post: 82430" data-attributes="member: 2624"><p>It's known that inflammation is associated with (among other things) metabolic syndrome and obesity. Preliminary evidence suggested that resveratrol - popular/widely used as a dietary supplement - had both anti-inflammatory and positive metabolic effects and there was hope such effects could be demonstrated in a clinical/therapeutic setting. </p><p></p><ul> <li data-xf-list-type="ul">A randomized, placebo-controlled, double-blind study was undertaken with the enrollment of middle-aged, community-dwelling men with metabolic syndrome into one of three groups. Average age was 49.5 years, body mass index was 33.8, and waist circumference was 115 cm.</li> <li data-xf-list-type="ul">Daily oral supplementation with 1000mg of resveratrol/150mg of resveratrol/placebo for 16 weeks.</li> <li data-xf-list-type="ul">Patient blood draws measured high-sensitivity C-reactive protein (hs-CRP), circulating lipids, inflammatory markers were sought and evaluated in circulation and adipose/muscle tissue biopsy specimens, while glucose metabolism and visceral fat deposition were evaluated as well.</li> </ul><p></p><p><strong>Results</strong></p><p></p><ul> <li data-xf-list-type="ul">Resveratrol did not lower circulating levels of: hs-CRP, interleukin 6, or soluble urokinase plasminogen activator receptor in plasma. Inflammatory gene expression remained unchanged in adipose and muscle tissue.</li> <li data-xf-list-type="ul">Resveratrol had no beneficial effect on blood pressure, body composition, lipid deposition in the liver or striated muscle.</li> <li data-xf-list-type="ul">Resveratrol had no beneficial effect on lipid metabolism</li> <li data-xf-list-type="ul">Resveratrol increased total cholesterol, LDL cholesterol, and fructosamine.</li> </ul><p></p><p><em>Journal of Clinical Endocrinology & Metabolism, 2017 May 1.</em></p><p><em></em></p><p><em></em><a href="https://www.ncbi.nlm.nih.gov/m/pubmed/28182820/" target="_blank">https://www.ncbi.nlm.nih.gov/m/pubmed/28182820/</a></p></blockquote><p></p>
[QUOTE="CoastWatcher, post: 82430, member: 2624"] It's known that inflammation is associated with (among other things) metabolic syndrome and obesity. Preliminary evidence suggested that resveratrol - popular/widely used as a dietary supplement - had both anti-inflammatory and positive metabolic effects and there was hope such effects could be demonstrated in a clinical/therapeutic setting. [LIST] [*]A randomized, placebo-controlled, double-blind study was undertaken with the enrollment of middle-aged, community-dwelling men with metabolic syndrome into one of three groups. Average age was 49.5 years, body mass index was 33.8, and waist circumference was 115 cm. [*]Daily oral supplementation with 1000mg of resveratrol/150mg of resveratrol/placebo for 16 weeks. [*]Patient blood draws measured high-sensitivity C-reactive protein (hs-CRP), circulating lipids, inflammatory markers were sought and evaluated in circulation and adipose/muscle tissue biopsy specimens, while glucose metabolism and visceral fat deposition were evaluated as well. [/LIST] [B]Results[/B] [LIST] [*]Resveratrol did not lower circulating levels of: hs-CRP, interleukin 6, or soluble urokinase plasminogen activator receptor in plasma. Inflammatory gene expression remained unchanged in adipose and muscle tissue. [*]Resveratrol had no beneficial effect on blood pressure, body composition, lipid deposition in the liver or striated muscle. [*]Resveratrol had no beneficial effect on lipid metabolism [*]Resveratrol increased total cholesterol, LDL cholesterol, and fructosamine. [/LIST] [I]Journal of Clinical Endocrinology & Metabolism, 2017 May 1. [/I][URL]https://www.ncbi.nlm.nih.gov/m/pubmed/28182820/[/URL] [/QUOTE]
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General Health & Fitness
Nutrition and Supplements
Resveratrol: No Impact on Metabolic Syndrome, Negatively Impacts Certain Markers
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