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Testosterone Replacement, Low T, HCG, & Beyond
Clomid for PCT, fertility or low T
Restoring spermatogenesis in hypogonadotrophic hypogonadism
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<blockquote data-quote="madman" data-source="post: 241340" data-attributes="member: 13851"><p><strong>*</strong><em><strong>The findings suggest that normal qualitative and quantitative sperm production is best maintained in the presence of both FSH- and LH-induced testosterone secretion. Human chorionic gonadotrophin (hCG) in conjunction with FSH is a common regimen for inducing spermatogenesis </strong></em></p><p></p><p><strong>*<em><strong>Although hMG has both FSH and LH activity, FSH activity predominates, and LH activity is so low that fertility requires a combination of hCG and hMG</strong></em></strong></p><p></p><p><em><strong>*More recently, highly pure urinary FSH preparations have been created, with higher specific activity than hMG. Recombinant human FSH formulations have greater purity and specific activity than any urinary preparation and no inherent LH activity</strong></em></p><p></p><p><strong>*<em><strong>Typically, hCG alone at a dose of 1000IU on alternate days or twice weekly is usually used to start gonadotrophin therapy, with the dose titrated based on trough testosterone levels and testicular development</strong></em></strong></p><p><strong></strong></p><p><strong>*<em>Due to residual FSH secretion, spermatogenesis can be begun with hCG alone in most individuals with bigger testes at baseline</em></strong></p><p><strong></strong></p><p><strong>*<em>Once there is a plateau in the response to hCG, which typically occurs at around 6 months, therapy with FSH (in one of the three forms described above) should be added at a dose of 75IU on 3 days per week. If sperm output and testicular growth remain suboptimal, the dose of FSH can be gradually increased to 150IU daily</em></strong></p><p><strong></strong></p><p><strong>*<em>Gynaecomastia is the most prevalent side effect of gonadotrophin therapy and is caused by increased oestradiol release due to hCG activation of aromatase</em></strong></p><p><strong></strong></p><p><strong>*<em>Pulsatile administration of GnRH, which can be via a programmable, portable mini-infusion pump, provides an alternative to gonadotrophin therapy.<u> FSH–hCG therapy provides two advantages over GnRH therapy</u>: subcutaneous delivery and greater efficacy in cases of GnRH receptor mutation (about 10% of normosmic congenital hypogonadotrophic hypogonadism)</em></strong></p></blockquote><p></p>
[QUOTE="madman, post: 241340, member: 13851"] [B]*[/B][I][B]The findings suggest that normal qualitative and quantitative sperm production is best maintained in the presence of both FSH- and LH-induced testosterone secretion. Human chorionic gonadotrophin (hCG) in conjunction with FSH is a common regimen for inducing spermatogenesis [/B][/I] [B]*[I][B]Although hMG has both FSH and LH activity, FSH activity predominates, and LH activity is so low that fertility requires a combination of hCG and hMG[/B][/I][/B] [I][B]*More recently, highly pure urinary FSH preparations have been created, with higher specific activity than hMG. Recombinant human FSH formulations have greater purity and specific activity than any urinary preparation and no inherent LH activity[/B][/I] [B]*[I][B]Typically, hCG alone at a dose of 1000IU on alternate days or twice weekly is usually used to start gonadotrophin therapy, with the dose titrated based on trough testosterone levels and testicular development[/B][/I] *[I]Due to residual FSH secretion, spermatogenesis can be begun with hCG alone in most individuals with bigger testes at baseline[/I] *[I]Once there is a plateau in the response to hCG, which typically occurs at around 6 months, therapy with FSH (in one of the three forms described above) should be added at a dose of 75IU on 3 days per week. If sperm output and testicular growth remain suboptimal, the dose of FSH can be gradually increased to 150IU daily[/I] *[I]Gynaecomastia is the most prevalent side effect of gonadotrophin therapy and is caused by increased oestradiol release due to hCG activation of aromatase[/I] *[I]Pulsatile administration of GnRH, which can be via a programmable, portable mini-infusion pump, provides an alternative to gonadotrophin therapy.[U] FSH–hCG therapy provides two advantages over GnRH therapy[/U]: subcutaneous delivery and greater efficacy in cases of GnRH receptor mutation (about 10% of normosmic congenital hypogonadotrophic hypogonadism)[/I][/B] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Clomid for PCT, fertility or low T
Restoring spermatogenesis in hypogonadotrophic hypogonadism
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