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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Responses of Different Doses of Testosterone Injections on Body Composition, Strength, etc.
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<blockquote data-quote="Nelson Vergel" data-source="post: 144178" data-attributes="member: 3"><p style="margin-left: 20px"></p> <p style="margin-left: 20px">Comment: 125 mg per week was the lowest dose that provided statistically significant changes in lean body mass and fat mass.</p> <p style="margin-left: 20px"></p> <p style="margin-left: 20px">PAPER ATTACHED</p> <p style="margin-left: 20px"><strong>Testosterone dose-response relationships in healthy young men.</strong></p> <p style="margin-left: 20px"></p> <p style="margin-left: 20px">Bhasin S, et al.</p> <p style="margin-left: 20px"></p> <p style="margin-left: 20px">Am J Physiol Endocrinol Metab. 2001 Dec;281(6):E1172-81.</p> <p style="margin-left: 20px"></p> <p style="margin-left: 20px">Full paper PDF attached below.</p> <p style="margin-left: 20px"></p> <p style="margin-left: 20px"><strong>Abstract</strong></p> <p style="margin-left: 20px"></p> <p style="margin-left: 20px">Testosterone increases muscle mass and strength and regulates other physiological processes, but we do not know whether testosterone effects are dose dependent and whether dose requirements for maintaining various androgen-dependent processes are similar.</p> <p style="margin-left: 20px"></p> <p style="margin-left: 20px">To determine the effects of graded doses of testosterone on body composition, muscle size, strength, power, sexual and cognitive functions, prostate-specific antigen (PSA), plasma lipids, hemoglobin, and insulin-like growth factor I (IGF-I) levels, 61 eugonadal men, 18-35 yr, were randomized to one of five groups to receive monthly injections of a long-acting gonadotropin-releasing hormone (GnRH) agonist, to suppress endogenous testosterone secretion, and weekly injections of 25, 50, 125, 300, or 600 mg of testosterone enanthate for 20 wk.</p> <p style="margin-left: 20px"></p> <p style="margin-left: 20px">Energy and protein intakes were standardized.</p> <p style="margin-left: 20px"></p> <p style="margin-left: 20px">The administration of the GnRH agonist plus graded doses of testosterone enanthate injections resulted in mean nadir (lowest level in the week) testosterone (ng/dL) concentrations of:</p> <p style="margin-left: 20px"></p> <p style="margin-left: 20px">253 for 25 mg/week</p> <p style="margin-left: 20px">306 for 50 mg/week</p> <p style="margin-left: 20px">542 for 125 mg/week</p> <p style="margin-left: 20px">1,345 for 300 mg/week</p> <p style="margin-left: 20px">and 2,370 ng/dl for 600 mg/week</p> <p style="margin-left: 20px"></p> <p style="margin-left: 20px"></p> <p style="margin-left: 20px"><strong>Fat-free mass </strong>increased dose dependently in men receiving 125, 300, or 600 mg of testosterone weekly (change +3.4, 5.2, and 7.9 kg, respectively). The changes in fat-free mass were highly dependent on testosterone dose (P = 0.0001) and correlated with log testosterone concentrations (r = 0.73, P = 0.0001).</p> <p style="margin-left: 20px"></p> <p style="margin-left: 20px">Changes in <strong>leg press strength, leg power, thigh and quadriceps muscle volumes, hemoglobin, and IGF-I</strong> were positively correlated with testosterone concentrations (meaning they increase proportionally with increase T dose), whereas changes in <strong>fat mass and plasma high-density lipoprotein (HDL) cholesterol </strong>were negatively correlated (they decreased with higher T doses).</p> <p style="margin-left: 20px"></p> <p style="margin-left: 20px"><strong>Sexual function, visual-spatial cognition and mood, and PSA levels</strong> did not change significantly at any dose. (This is surprising, but we should remember these are young healthy men who had normal testosterone at start of the study).</p> <p style="margin-left: 20px"></p> <p style="margin-left: 20px">We conclude that changes in circulating testosterone concentrations, induced by GnRH agonist and testosterone administration, are associated with testosterone dose- and concentration-dependent changes in fat-free mass, muscle size, strength and power, fat mass, hemoglobin, HDL cholesterol, and IGF-I levels, in conformity with a single linear dose-response relationship. However, different androgen-dependent processes have different testosterone dose-response relationships.</p> <p style="margin-left: 20px"></p> <p style="margin-left: 20px"><strong><a href="https://www.excelmale.com/forum/showthread.php?1519-How-long-does-testosterone-take-to-show-effects" target="_blank">How long does testosterone take to show effects?</a></strong></p> <p style="margin-left: 20px"></p> <p style="margin-left: 20px"><img src="https://www.excelmale.com/attachment.php?attachmentid=1718&d=1451595505" class="bbImage" alt="" data-url="https://www.excelmale.com/attachment.php?attachmentid=1718&d=1451595505" style="" /></p> <p style="margin-left: 20px"></p> <p style="margin-left: 20px"></p> <p style="margin-left: 20px"><a href="http://www.testosteronewisdom.com/wp-content/uploads/2018/01/testosterone-body-composition.pdf" target="_blank">Download Attachment</a></p> <p style="margin-left: 20px"></p><p></p><p></p><p>The post <a href="https://www.testosteronewisdom.com/2856/responses-of-different-doses-of-testosterone-injections-on-body-composition-strength-etc/" target="_blank">Responses of Different Doses of Testosterone Injections on Body Composition, Strength, etc.</a> appeared first on <a href="https://www.testosteronewisdom.com" target="_blank">Testosterone Wisdom</a>.</p><p></p><p><a href="https://www.testosteronewisdom.com/2856/responses-of-different-doses-of-testosterone-injections-on-body-composition-strength-etc/" target="_blank">Continue reading...</a></p></blockquote><p></p>
[QUOTE="Nelson Vergel, post: 144178, member: 3"] [INDENT][/INDENT] [INDENT]Comment: 125 mg per week was the lowest dose that provided statistically significant changes in lean body mass and fat mass.[/INDENT] [INDENT][/INDENT] [INDENT]PAPER ATTACHED[/INDENT] [INDENT][B]Testosterone dose-response relationships in healthy young men.[/B][/INDENT] [INDENT][/INDENT] [INDENT]Bhasin S, et al.[/INDENT] [INDENT][/INDENT] [INDENT]Am J Physiol Endocrinol Metab. 2001 Dec;281(6):E1172-81.[/INDENT] [INDENT][/INDENT] [INDENT]Full paper PDF attached below.[/INDENT] [INDENT][/INDENT] [INDENT][B]Abstract[/B][/INDENT] [INDENT][/INDENT] [INDENT]Testosterone increases muscle mass and strength and regulates other physiological processes, but we do not know whether testosterone effects are dose dependent and whether dose requirements for maintaining various androgen-dependent processes are similar.[/INDENT] [INDENT][/INDENT] [INDENT]To determine the effects of graded doses of testosterone on body composition, muscle size, strength, power, sexual and cognitive functions, prostate-specific antigen (PSA), plasma lipids, hemoglobin, and insulin-like growth factor I (IGF-I) levels, 61 eugonadal men, 18-35 yr, were randomized to one of five groups to receive monthly injections of a long-acting gonadotropin-releasing hormone (GnRH) agonist, to suppress endogenous testosterone secretion, and weekly injections of 25, 50, 125, 300, or 600 mg of testosterone enanthate for 20 wk.[/INDENT] [INDENT][/INDENT] [INDENT]Energy and protein intakes were standardized.[/INDENT] [INDENT][/INDENT] [INDENT]The administration of the GnRH agonist plus graded doses of testosterone enanthate injections resulted in mean nadir (lowest level in the week) testosterone (ng/dL) concentrations of:[/INDENT] [INDENT][/INDENT] [INDENT]253 for 25 mg/week[/INDENT] [INDENT]306 for 50 mg/week[/INDENT] [INDENT]542 for 125 mg/week[/INDENT] [INDENT]1,345 for 300 mg/week[/INDENT] [INDENT]and 2,370 ng/dl for 600 mg/week[/INDENT] [INDENT][/INDENT] [INDENT][/INDENT] [INDENT][B]Fat-free mass [/B]increased dose dependently in men receiving 125, 300, or 600 mg of testosterone weekly (change +3.4, 5.2, and 7.9 kg, respectively). The changes in fat-free mass were highly dependent on testosterone dose (P = 0.0001) and correlated with log testosterone concentrations (r = 0.73, P = 0.0001).[/INDENT] [INDENT][/INDENT] [INDENT]Changes in [B]leg press strength, leg power, thigh and quadriceps muscle volumes, hemoglobin, and IGF-I[/B] were positively correlated with testosterone concentrations (meaning they increase proportionally with increase T dose), whereas changes in [B]fat mass and plasma high-density lipoprotein (HDL) cholesterol [/B]were negatively correlated (they decreased with higher T doses).[/INDENT] [INDENT][/INDENT] [INDENT][B]Sexual function, visual-spatial cognition and mood, and PSA levels[/B] did not change significantly at any dose. (This is surprising, but we should remember these are young healthy men who had normal testosterone at start of the study).[/INDENT] [INDENT][/INDENT] [INDENT]We conclude that changes in circulating testosterone concentrations, induced by GnRH agonist and testosterone administration, are associated with testosterone dose- and concentration-dependent changes in fat-free mass, muscle size, strength and power, fat mass, hemoglobin, HDL cholesterol, and IGF-I levels, in conformity with a single linear dose-response relationship. However, different androgen-dependent processes have different testosterone dose-response relationships.[/INDENT] [INDENT][/INDENT] [INDENT][B][URL='https://www.excelmale.com/forum/showthread.php?1519-How-long-does-testosterone-take-to-show-effects']How long does testosterone take to show effects?[/URL][/B][/INDENT] [INDENT][/INDENT] [INDENT][IMG]https://www.excelmale.com/attachment.php?attachmentid=1718&d=1451595505[/IMG][/INDENT] [INDENT][/INDENT] [INDENT][/INDENT] [INDENT][URL='http://www.testosteronewisdom.com/wp-content/uploads/2018/01/testosterone-body-composition.pdf']Download Attachment[/URL][/INDENT] [INDENT][/INDENT] The post [URL='https://www.testosteronewisdom.com/2856/responses-of-different-doses-of-testosterone-injections-on-body-composition-strength-etc/']Responses of Different Doses of Testosterone Injections on Body Composition, Strength, etc.[/URL] appeared first on [URL='https://www.testosteronewisdom.com']Testosterone Wisdom[/URL]. [URL='https://www.testosteronewisdom.com/2856/responses-of-different-doses-of-testosterone-injections-on-body-composition-strength-etc/']Continue reading...[/URL] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone and Men's Health Articles
Responses of Different Doses of Testosterone Injections on Body Composition, Strength, etc.
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