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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Relationship between insulin resistance, estradiol, aromatase, testosterone replacement, and water retention
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<blockquote data-quote="Nelson Vergel" data-source="post: 201761" data-attributes="member: 3"><p>I am just speculating here. After many years of reading posts on here and with my own experience, I think these are the main factors that may explain why someone may not feel better on TRT:</p><p></p><p>1- They never needed it. They started TRT with baseline total T over 400 ng/dL and did not address issues like sleep quality, sedentary life style, high body weight, and potential stress.</p><p></p><p>2- They used too high of a dose. This increased their hematocrit considerably with the resulting quality of life issues caused by higher blood viscosity.</p><p></p><p>3- TRT made their sleep apnea worse (Obstructive or central in nature).</p><p></p><p>4- They donated blood too frequently and could not catch up in their iron and ferritin loss. Many never got those two levels even tested.</p><p></p><p>5- They crashed their estradiol with anastrozole.</p><p></p><p>6- Their water retention was excessive, with increase blood pressure and feeling "out of breath".</p><p></p><p>7- They did not address and treat their depression. There is so much TRT can do but improving depression unrelated to low T is hard to accomplish without treatment and therapy.</p><p></p><p>8- They never looked deeply at thyroid dysfunction with a full panel that includes antibodies and reverse T3.</p><p></p><p>9- They never improved their diet and alcohol use.</p><p></p><p>10- None of the above...just bad luck.</p><p></p><p>I will think of more and add later. These are the most obvious ones.</p></blockquote><p></p>
[QUOTE="Nelson Vergel, post: 201761, member: 3"] I am just speculating here. After many years of reading posts on here and with my own experience, I think these are the main factors that may explain why someone may not feel better on TRT: 1- They never needed it. They started TRT with baseline total T over 400 ng/dL and did not address issues like sleep quality, sedentary life style, high body weight, and potential stress. 2- They used too high of a dose. This increased their hematocrit considerably with the resulting quality of life issues caused by higher blood viscosity. 3- TRT made their sleep apnea worse (Obstructive or central in nature). 4- They donated blood too frequently and could not catch up in their iron and ferritin loss. Many never got those two levels even tested. 5- They crashed their estradiol with anastrozole. 6- Their water retention was excessive, with increase blood pressure and feeling "out of breath". 7- They did not address and treat their depression. There is so much TRT can do but improving depression unrelated to low T is hard to accomplish without treatment and therapy. 8- They never looked deeply at thyroid dysfunction with a full panel that includes antibodies and reverse T3. 9- They never improved their diet and alcohol use. 10- None of the above...just bad luck. I will think of more and add later. These are the most obvious ones. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Relationship between insulin resistance, estradiol, aromatase, testosterone replacement, and water retention
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