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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Relationship between insulin resistance, estradiol, aromatase, testosterone replacement, and water retention
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<blockquote data-quote="Cataceous" data-source="post: 201289" data-attributes="member: 38109"><p>This is good, because success requires persistence. Your results show that there can be more to this than testosterone and estradiol. Sometimes it's necessary to go back to basics. Are thyroid and adrenal hormones in good shape? Lowish, but in-range thyroid hormones can be a problem. It's commonly said that TRT won't work well if these other hormones aren't right.</p><p></p><p>[USER=42611]@Cyclingislife[/USER] has a good suggestion in general; overdosing is a common problem in the TRT world. But it does seem as though you've tried a lot of protocols, including some at fairly low levels. One way to take it a step further is to dose the testosterone so that the daily peak in serum levels is normal and the daily trough is about 40% lower. This can be accomplished with daily injections of an appropriate blend of propionate and a longer ester.</p><p></p><p>While the dosing stuff is worth trying, I expect it's too subtle for what you're trying to fix. A likely culprit is TRT's disruption of upstream hormones, which include kisspeptin, GnRH, LH, FSH, progesterone, DHEA and pregnenolone. Though tedious, it is possible to restore levels of these hormones to the point of reducing some amount of TRT-induced dysfunction. If this is impractical then the main alternative is to forgo regular TRT and instead boost testosterone in a non-suppressive manner. Two options for this are testosterone nasal gel and enclomiphene.</p><p></p><p>Another avenue to pursue is neurotransmitters. There's a range of supplements and medications that can be used to boost acetylcholine and dopamine. Some examples <a href="https://www.peaktestosterone.com/forum/index.php?topic=9644.0" target="_blank">here</a>.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 201289, member: 38109"] This is good, because success requires persistence. Your results show that there can be more to this than testosterone and estradiol. Sometimes it's necessary to go back to basics. Are thyroid and adrenal hormones in good shape? Lowish, but in-range thyroid hormones can be a problem. It's commonly said that TRT won't work well if these other hormones aren't right. [USER=42611]@Cyclingislife[/USER] has a good suggestion in general; overdosing is a common problem in the TRT world. But it does seem as though you've tried a lot of protocols, including some at fairly low levels. One way to take it a step further is to dose the testosterone so that the daily peak in serum levels is normal and the daily trough is about 40% lower. This can be accomplished with daily injections of an appropriate blend of propionate and a longer ester. While the dosing stuff is worth trying, I expect it's too subtle for what you're trying to fix. A likely culprit is TRT's disruption of upstream hormones, which include kisspeptin, GnRH, LH, FSH, progesterone, DHEA and pregnenolone. Though tedious, it is possible to restore levels of these hormones to the point of reducing some amount of TRT-induced dysfunction. If this is impractical then the main alternative is to forgo regular TRT and instead boost testosterone in a non-suppressive manner. Two options for this are testosterone nasal gel and enclomiphene. Another avenue to pursue is neurotransmitters. There's a range of supplements and medications that can be used to boost acetylcholine and dopamine. Some examples [URL='https://www.peaktestosterone.com/forum/index.php?topic=9644.0']here[/URL]. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Relationship between insulin resistance, estradiol, aromatase, testosterone replacement, and water retention
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