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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Relationship between insulin resistance, estradiol, aromatase, testosterone replacement, and water retention
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<blockquote data-quote="nathan toney" data-source="post: 201119" data-attributes="member: 39236"><p>Hello gentlemen,</p><p>Nate here again. I have struggled to get dialed in on TRT for about 12 years. I have tried every protocol (never less than 8 weeks) other than Nebido (not interested). Everything from 50mg per week to 200mg per week, creams, gels, test prop/cyp blend and AI's. ED, EOD, E3D, E4D, E5D, weekly, 2 weeks, 3 weeks. Every time I reach a point where the water retention, actively feeling weaker, loss of libido, and foggier thinking is my reason for D/C'g TRT. The only time I have a period of time feeling great on TRT is after I have abstained from use for a minimum of 3 months (and I mean F%$@ing GREAT - strong, smart, lean, great sleep, great workouts, great libido, etc - then it passes if I continue TRT). When I come off TRT I pass through a short period of time where I feel slightly better, then I start having muscle tears, injuries, losing muscle, weakness, no libido. Last year my Dr wanted me to try an aromatase inhibitor. Long story short it made things worse. I did a 3 week washout and then most recently started daily TC injections for 8 weeks (no ancillaries) at 200mg/wk. Again I never felt any benefit and water retention, slow thinking, weakness, no libido (my usual reasons for quitting TRT) was my reason for D/C'g TRT this go around. My SHBG is never lower than 29. I am currently off TRT for 8 days. This week I convinced my Dr to prescribe Metformin. I have had fasting BG around 100 for decades. Even on Keto, low carb, fasting. I believe we have put to bed that AI's don't work and that E2 is not the problem (the Danny Bossa guys) but I'm not sure. </p><p>Here is what I'm wondering: </p><p>Can insulin resistance get worse on testosterone partly due to E2, causing me to pass through a period of time feeling excellent? </p><p>Is there a relationship between insulin resistance and E2 that makes some low T men unable to maintain benefit? </p><p>Can E2 increase insulin resistance? </p><p>I am a seeker by nature, so I won't stop trying to feel better.</p><p>Thanks for any responses,</p><p>Nate</p></blockquote><p></p>
[QUOTE="nathan toney, post: 201119, member: 39236"] Hello gentlemen, Nate here again. I have struggled to get dialed in on TRT for about 12 years. I have tried every protocol (never less than 8 weeks) other than Nebido (not interested). Everything from 50mg per week to 200mg per week, creams, gels, test prop/cyp blend and AI's. ED, EOD, E3D, E4D, E5D, weekly, 2 weeks, 3 weeks. Every time I reach a point where the water retention, actively feeling weaker, loss of libido, and foggier thinking is my reason for D/C'g TRT. The only time I have a period of time feeling great on TRT is after I have abstained from use for a minimum of 3 months (and I mean F%$@ing GREAT - strong, smart, lean, great sleep, great workouts, great libido, etc - then it passes if I continue TRT). When I come off TRT I pass through a short period of time where I feel slightly better, then I start having muscle tears, injuries, losing muscle, weakness, no libido. Last year my Dr wanted me to try an aromatase inhibitor. Long story short it made things worse. I did a 3 week washout and then most recently started daily TC injections for 8 weeks (no ancillaries) at 200mg/wk. Again I never felt any benefit and water retention, slow thinking, weakness, no libido (my usual reasons for quitting TRT) was my reason for D/C'g TRT this go around. My SHBG is never lower than 29. I am currently off TRT for 8 days. This week I convinced my Dr to prescribe Metformin. I have had fasting BG around 100 for decades. Even on Keto, low carb, fasting. I believe we have put to bed that AI's don't work and that E2 is not the problem (the Danny Bossa guys) but I'm not sure. Here is what I'm wondering: Can insulin resistance get worse on testosterone partly due to E2, causing me to pass through a period of time feeling excellent? Is there a relationship between insulin resistance and E2 that makes some low T men unable to maintain benefit? Can E2 increase insulin resistance? I am a seeker by nature, so I won't stop trying to feel better. Thanks for any responses, Nate [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Relationship between insulin resistance, estradiol, aromatase, testosterone replacement, and water retention
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