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I'm a bit unhappy with the authors stating that "IA compared to LC-MS/MS in hypogonadal men overestimates significantly both the prevalence of biochemical Hy and TRT compensation both for TT and cfT" or in other words that IA underestimate TT levels, considering this study used CMIA DxI800 Beckman Coulter (IA) specifically, and other IAs, like Roche Elecsys commonly used in UK overestimates TT. So the statement would be incorrect, without specifying that it's only true for the specific assay used. And it can mislead someone who didn't process the study properly, to think that their TT level is actually higher then the IA test result, while in fact it could be the opposite, depending on which IA was used.