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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Regaining Fertility; TRT+HCG+FSH
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<blockquote data-quote="Sides" data-source="post: 151194" data-attributes="member: 31749"><p>TRT and FSH by itself is NOT enough to maintain fertility. You need HCG to maintain high levels of intra-testicular testosterone. Use all three for maximum fertility, TRT + HCG + FSH.</p><p></p><p>Quoted from the following study:</p><p></p><p><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854084/" target="_blank">Recovery of spermatogenesis following testosterone replacement therapy or anabolic-androgenic steroid use</a> </p><p></p><p></p><p>"FSH given alone or in combination with testosterone has proven unsuccessful at inducing spermatogenesis or maintaining spermatogenesis in those previously induced with hCG/FSH (hCG 1500 IU and HMG 150 IU both subcutaneous and 3 times per week), confirming the need for maintenance of elevated ITT.<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854084/#ref46" target="_blank">46</a> However, long-term use of hCG alone can induce spermatogenesis in up to 70% of patients, with a greater effect seen in men with initial testis length >4 cm, but further improvement is appreciated with the addition of FSH (HMG) suggesting a timelier recovery with both gonadotropins.<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854084/#ref47" target="_blank">47</a> The success of inducing spermatogenesis with a combination of hCG and FSH is supported by several studies (<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854084/table/T1/" target="_blank"><strong>Table 1</strong></a>).<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854084/#ref41" target="_blank">41</a>,<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854084/#ref42" target="_blank">42</a>,<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854084/#ref45" target="_blank">45</a>,<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854084/#ref48" target="_blank">48</a>,<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854084/#ref49" target="_blank">49</a>,<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854084/#ref50" target="_blank">50</a>,<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854084/#ref51" target="_blank">51</a>,<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854084/#ref52" target="_blank">52</a>,<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854084/#ref53" target="_blank">53</a> "</p></blockquote><p></p>
[QUOTE="Sides, post: 151194, member: 31749"] TRT and FSH by itself is NOT enough to maintain fertility. You need HCG to maintain high levels of intra-testicular testosterone. Use all three for maximum fertility, TRT + HCG + FSH. Quoted from the following study: [URL="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854084/"]Recovery of spermatogenesis following testosterone replacement therapy or anabolic-androgenic steroid use[/URL] "FSH given alone or in combination with testosterone has proven unsuccessful at inducing spermatogenesis or maintaining spermatogenesis in those previously induced with hCG/FSH (hCG 1500 IU and HMG 150 IU both subcutaneous and 3 times per week), confirming the need for maintenance of elevated ITT.[URL='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854084/#ref46']46[/URL] However, long-term use of hCG alone can induce spermatogenesis in up to 70% of patients, with a greater effect seen in men with initial testis length >4 cm, but further improvement is appreciated with the addition of FSH (HMG) suggesting a timelier recovery with both gonadotropins.[URL='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854084/#ref47']47[/URL] The success of inducing spermatogenesis with a combination of hCG and FSH is supported by several studies ([URL='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854084/table/T1/'][B]Table 1[/B][/URL]).[URL='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854084/#ref41']41[/URL],[URL='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854084/#ref42']42[/URL],[URL='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854084/#ref45']45[/URL],[URL='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854084/#ref48']48[/URL],[URL='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854084/#ref49']49[/URL],[URL='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854084/#ref50']50[/URL],[URL='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854084/#ref51']51[/URL],[URL='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854084/#ref52']52[/URL],[URL='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854084/#ref53']53[/URL] " [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Regaining Fertility; TRT+HCG+FSH
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