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Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
Reference Intervals for Free Testosterone in Adult Men Measured Using a Standardized Equilibrium Dialysis Procedure
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<blockquote data-quote="tareload" data-source="post: 236802"><p>Fig. 4 is the "money" graph as it is sometimes called:</p><p></p><p>[ATTACH=full]26308[/ATTACH]</p><p></p><p>I am too impatient today to wait for the next paper so here you go. You got it here first on [USER=3]@Nelson Vergel[/USER] 's ExcelMale.</p><p></p><p>Given the Tru-T website locks you down after a few tries I didn't fill out the whole table but covered the boundaries:</p><p></p><p>[ATTACH=full]26309[/ATTACH]</p><p></p><p></p><p>Hence, I can construct a plot of fT/TT vs SHBG for two extreme cases:</p><p>(1) TT of 100 ng/dl</p><p>(2) TT of 1100 ng/dl</p><p></p><p>[ATTACH=full]26312[/ATTACH]</p><p>[ATTACH=full]26313[/ATTACH]</p><p></p><p></p><p>Plot fT/TT ratio vs SHBG for both models (cfTV and Tru-T) and compare with data in Fig. 4 above:</p><p></p><p>Vermeulen:</p><p></p><p>[ATTACH=full]26314[/ATTACH]</p><p>Note I just superimposed the graphs by lining up the axes since I am not going to digitize all this data.</p><p></p><p>Tru-T:</p><p>[ATTACH=full]26315[/ATTACH]</p><p></p><p></p><p>In summary, neither model picks up those young guys running fT of 36 ng/dl with a TT of 600 ng/dl. However, you can collapse all of the Vermeulen output into a tight band irrespective of the TT level (underpredicts %fT on this data set across the board). Historically where Tru-T really seems to struggle is with guys who have high TT and high SHBG (====> really overpredicts %fT for guys on higher dose TRT/TOT).</p><p></p><p>These experimental data indicate guys with high SHBG still above 1% fT.</p><p></p><p>EDIT: graphs corrected as I had not superposed the experimental data with the model data properly. As good I can do without raw data and unlocked Tru-T model to complete parity plot.</p><p></p><p>Figs. 1A and 1B are very nice. Thanks again [USER=13851]@madman[/USER]. How much time has been wasted comparing fT measurements that have not been standardized.</p></blockquote><p></p>
[QUOTE="tareload, post: 236802"] Fig. 4 is the "money" graph as it is sometimes called: [ATTACH type="full" alt="1666873421523.png"]26308[/ATTACH] I am too impatient today to wait for the next paper so here you go. You got it here first on [USER=3]@Nelson Vergel[/USER] 's ExcelMale. Given the Tru-T website locks you down after a few tries I didn't fill out the whole table but covered the boundaries: [ATTACH type="full" alt="1666873471172.png"]26309[/ATTACH] Hence, I can construct a plot of fT/TT vs SHBG for two extreme cases: (1) TT of 100 ng/dl (2) TT of 1100 ng/dl [ATTACH type="full" alt="1666874190321.png"]26312[/ATTACH] [ATTACH type="full" alt="1666874248995.png"]26313[/ATTACH] Plot fT/TT ratio vs SHBG for both models (cfTV and Tru-T) and compare with data in Fig. 4 above: Vermeulen: [ATTACH type="full" alt="1666874796544.png"]26314[/ATTACH] Note I just superimposed the graphs by lining up the axes since I am not going to digitize all this data. Tru-T: [ATTACH type="full" alt="1666874822923.png"]26315[/ATTACH] In summary, neither model picks up those young guys running fT of 36 ng/dl with a TT of 600 ng/dl. However, you can collapse all of the Vermeulen output into a tight band irrespective of the TT level (underpredicts %fT on this data set across the board). Historically where Tru-T really seems to struggle is with guys who have high TT and high SHBG (====> really overpredicts %fT for guys on higher dose TRT/TOT). These experimental data indicate guys with high SHBG still above 1% fT. EDIT: graphs corrected as I had not superposed the experimental data with the model data properly. As good I can do without raw data and unlocked Tru-T model to complete parity plot. Figs. 1A and 1B are very nice. Thanks again [USER=13851]@madman[/USER]. How much time has been wasted comparing fT measurements that have not been standardized. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
Reference Intervals for Free Testosterone in Adult Men Measured Using a Standardized Equilibrium Dialysis Procedure
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