Reducing Major Adverse Cardiac Events (MACE) with PDE5 Inhibitors

madman · Jul 14, 2023

E. David Crawford, MD, sits down with Robert A. Kloner, MD, Ph.D., and Raymond Rosen, MD, to discuss retrospective evidence of PDE5 inhibitors in preventing major adverse cardiac events (MACE) in men. Crawford, Kloner, and Rosen discuss a retrospective study examining occurrences of MACE in men which demonstrated a significant reduction in MACE in men using PDE5 inhibitors versus those who were not.

madman · Feb 10, 2024

Sildenafil, 25 Years Later - Excel Male Health Forum

Sildenafil: 25 Years Later – Summary Twenty-five years ago, the FDA’s approval of sildenafil (Viagra) radically reshaped the treatment of erectile dysfunction. Editor-in-Chief of Grand Rounds in Urology, E. David Crawford, MD, sits down to discuss the history and future of PDE5 inhibitors with...

www.excelmale.com

madman · Jul 18, 2025

Thread 'Managing Erectile Dysfunction & Heart Health'

Jul 18, 2025

Dr. Dapo lluyomade

* I think erectile dysfunction, we should really begin to think of erectile dysfunction as subclinical atherosclerosis until proven otherwise

Is your patient’s sexual dysfunction an early indicator of serious cardiovascular disease? In this episode of BackTable Urology, Dr. Amy Pearlman teams up with preventative cardiologist Dr. Dapo Iluyomade to discuss the relationship between erectile dysfunction (ED) and cardiovascular disease, and the holistic approach needed to prevent both of these chronic conditions from...

madman · Aug 12, 2025

Thread 'Muscle Mass, Testosterone & Erections: The Doctor's Blueprint for Men’s Health'

Aug 12, 2025

* the best overall marker for overall health in men is ERECTILE FUNCTION

* One of the most striking points from the discussion was Dr. Kohler’s perspective on erectile dysfunction (ED). He described it not just as a sexual problem, but as one of the earliest "check engine lights" for heart disease. The blood vessels to the penis are smaller than those in the heart, so plaque buildup (atherosclerosis) affects them first. Persistent erection issues can signal vascular problems that may soon affect your heart.

...

madman · Aug 15, 2025

Thread 'Erectile dysfunction: A vital sign for cardiovascular health'

Aug 15, 2025

* The P4 panel recommendations confirm that ED is a strong, independent predictor of cardiac events, even when traditional risk factors such as cholesterol, diabetes and blood pressure are controlled for. In short, ED is the body's "check engine light" for heart disease.

* Phosphodiesterase-5 (PDE5) inhibitors — such as sildenafil and tadalafil — remain first line therapy for ED. The P4 recommendations, however, suggest that these medications may offer more than symptom relief. Multiple large studies show that men taking PDE5 inhibitors have lower rates of heart...

madman · Aug 18, 2025

Thread 'Struggling with ED? Dr. Jeff Albaugh Breaks Down Causes, Treatments, and How to Take Back Control'

Aug 18, 2025

Great presentation!

I have been stressing this numerous times over the years.

ED is multifactorial and vascular issues are the most common cause.

Stop getting caught up on T, DHT, estradiol let alone the myth that one needs high FT/DHT!

T plays a small role.

What about testosterone?

* testosterone is a hormone that works all over the body and it has a small role with erections but it has a big role with libido or sex drive so it is important but the key essential components is blood flow and nervous conduction

* deep sleep is critical to...

madman · Aug 23, 2025

Thread 'Penile Doppler Explained: Normal Study vs Arterial Insufficiency and Venous Leak'

Aug 23, 2025

Penile Doppler ultrasound is a vital tool for evaluating vascular causes of erectile dysfunction. In a normal study, adequate arterial inflow is demonstrated by a peak systolic velocity (PSV) greater than 30–35 cm/s, and proper venous occlusion is confirmed by a low end diastolic velocity (EDV) approaching zero. This pattern supports the achievement and maintenance of a firm erection. In contrast, the abnormal case shows a PSV less than 25 cm/s, indicating arterial insufficiency, and a persistently elevated EDV of 5–9 cm/s with continuous diastolic flow...

madman · Oct 26, 2025

Thread 'The interplay of health and heart health on sexual function: understanding the impact of CVD on sexual dysfunction in men'

Oct 26, 2025

* Erectile dysfunction is a marker of underlying cardiac disease, but many doctors are just not asking!

@Nelson Vergel

This is powerful!

6:00-6:15

* You need to lose about 75% of the lumen of the coronary artery before you get your first cardiac symptom but if you lose even a small amount of the very small penile artery you get sexual problems

https://vimeo.com/1100857015?share=copy&fl=cl&fe=ci
VIDEO HERE