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Thyroid, Pregnenolone, Progesterone, DHEA, etc
Thyroid, DHEA, Pregnenolone, Progesterone, etc
Recovery of Thyroid Function After Stopping Thyroid Medication
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<blockquote data-quote="Nelson Vergel" data-source="post: 26694" data-attributes="member: 3"><p><strong>Recovery of Pituitary Thyrotropic Function after Withdrawal of Prolonged Thyroid-Suppression Therapy</strong></p><p></p><p>Apostolos G. Vagenakis, M.D., Lewis E. Braverman, M.D., Fereidoun Azizi, M.D., Gary I. Portnay, M.D., and Sidney H. Ingbar, M.D.</p><p>N Engl J Med 1975; 293:681-684<a href="http://www.nejm.org/toc/nejm/293/14/" target="_blank">October 2, 1975</a>DOI: 10.1056/NEJM197510022931402</p><p></p><p>Abstract</p><p></p><p></p><p>The pattern of thyrotropin secretion was analyzed in seven euthyroid women, before and after withdrawal of long-term thyroid hormone, by serial measurements of thyroid uptake, serum thyroxine, tri-iodothyronine, and thyrotropin concentrations, and the response to thyrotropin-releasing hormone. During exogenous hormone administration, uptake was suppressed, and serum thyrotropin concentrations before and after administration of thyrotropin-releasing hormone were undetectable. After withdrawal of exogenous hormone, thyrotropin secretory function was transiently impaired, as indicated by undetectable basal thyrotropin concentrations together with absence of response to thyrotropin-releasing hormone, and subsequently by normal values of basal thyrotropin concentration and normal responses to releasing hormone while serum thyroxine and tri-iodothyronine concentrations were subnormal. Decreased thyrotropin reserve persisted for two to five weeks.</p><p>Detectable values of serum thyrotropin ( <1.2 &#956;U per milliliter) and a normal uptake usually occurred concurrently in two to three weeks. <strong>Serum thyroxine concentration returned to normal at least four weeks after hormone withdrawal. (</strong>N Engl J Med 293:681&#8211;684, 1975)</p></blockquote><p></p>
[QUOTE="Nelson Vergel, post: 26694, member: 3"] [B]Recovery of Pituitary Thyrotropic Function after Withdrawal of Prolonged Thyroid-Suppression Therapy[/B] Apostolos G. Vagenakis, M.D., Lewis E. Braverman, M.D., Fereidoun Azizi, M.D., Gary I. Portnay, M.D., and Sidney H. Ingbar, M.D. N Engl J Med 1975; 293:681-684[URL="http://www.nejm.org/toc/nejm/293/14/"]October 2, 1975[/URL]DOI: 10.1056/NEJM197510022931402 Abstract The pattern of thyrotropin secretion was analyzed in seven euthyroid women, before and after withdrawal of long-term thyroid hormone, by serial measurements of thyroid uptake, serum thyroxine, tri-iodothyronine, and thyrotropin concentrations, and the response to thyrotropin-releasing hormone. During exogenous hormone administration, uptake was suppressed, and serum thyrotropin concentrations before and after administration of thyrotropin-releasing hormone were undetectable. After withdrawal of exogenous hormone, thyrotropin secretory function was transiently impaired, as indicated by undetectable basal thyrotropin concentrations together with absence of response to thyrotropin-releasing hormone, and subsequently by normal values of basal thyrotropin concentration and normal responses to releasing hormone while serum thyroxine and tri-iodothyronine concentrations were subnormal. Decreased thyrotropin reserve persisted for two to five weeks. Detectable values of serum thyrotropin ( <1.2 μU per milliliter) and a normal uptake usually occurred concurrently in two to three weeks. [B]Serum thyroxine concentration returned to normal at least four weeks after hormone withdrawal. ([/B]N Engl J Med 293:681–684, 1975) [/QUOTE]
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Thyroid, Pregnenolone, Progesterone, DHEA, etc
Thyroid, DHEA, Pregnenolone, Progesterone, etc
Recovery of Thyroid Function After Stopping Thyroid Medication
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