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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Re: (low) DHT...anyone using cream + injections
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<blockquote data-quote="Nelson Vergel" data-source="post: 27031" data-attributes="member: 3"><p>Here are some good discussions from the past on the subject of increasing DHT</p><p></p><p><strong><a href="https://www.excelmale.com/forum/showthread.php?1051-Scrotum-application-of-testosterone" target="_blank">Scrotum application of testosterone</a></strong></p><p></p><p></p><p>This is a German product that some guys import into the US:</p><p></p><p><strong><a href="https://www.excelmale.com/forum/showthread.php?1869-DHT-Gel-Shuts-Down-LH-FSH-Estradiol-and-T-But-Sustained-Sexual-Function" target="_blank">DHT Gel Shuts Down LH, FSH, Estradiol and T But Sustained Sexual Function</a></strong></p><p></p><p></p><p>and here is an interesting study with creatine:</p><p></p><p></p><p>Clin J Sport Med. 2009 Sep;19(5):399-404.</p><p></p><p><strong>Three weeks of creatine monohydrate supplementation affects dihydrotestosterone to testosterone ratio in college-aged rugby players.</strong></p><p></p><p>van der Merwe J1, Brooks NE, Myburgh KH.</p><p></p><p></p><p>Abstract</p><p></p><p>OBJECTIVE:</p><p>This study investigated resting concentrations of selected androgens after 3 weeks of creatine supplementation in male rugby players. It was hypothesized that the ratio of dihydrotestosterone (DHT, a biologically more active androgen) to testosterone (T) would change with creatine supplementation.</p><p></p><p>DESIGN:</p><p>Double-blind placebo-controlled crossover study with a 6-week washout period.</p><p></p><p>SETTING:</p><p>Rugby Institute in South Africa.</p><p></p><p>PARTICIPANTS:</p><p>College-aged rugby players (n = 20) volunteered for the study, which took place during the competitive season.</p><p></p><p>INTERVENTIONS:</p><p>Subjects loaded with creatine (25 g/day creatine with 25 g/day glucose) or placebo (50 g/day glucose) for 7 days followed by 14 days of maintenance (5 g/day creatine with 25 g/day glucose or 30 g/day glucose placebo).</p><p></p><p>MAIN OUTCOME MEASURES:</p><p>Serum T and DHT were measured and ratio calculated at baseline and after 7 days and 21 days of creatine supplementation (or placebo). Body composition measurements were taken at each time point.</p><p></p><p>RESULTS:</p><p>After 7 days of creatine loading, or a further 14 days of creatine maintenance dose, serum T levels did not change. However, levels of DHT increased by 56% after 7 days of creatine loading and remained 40% above baseline after 14 days maintenance (P < 0.001). The ratio of DHT:T also increased by 36% after 7 days creatine supplementation and remained elevated by 22% after the maintenance dose (P < 0.01).</p><p></p><p>CONCLUSIONS:</p><p>Creatine supplementation may, in part, act through an increased rate of conversion of T to DHT. Further investigation is warranted as a result of the high frequency of individuals using creatine supplementation and the long-term safety of alterations in circulating androgen composition. STATEMENT OF CLINICAL RELEVANCE: Although creatine is a widely used ergogenic aid, the mechanisms of action are incompletely understood, particularly in relation to dihydrotestosterone, and therefore the long-term clinical safety cannot be guaranteed.</p><p></p><p>Comment in</p><p>Creatine supplementation and DHT:T ratio in male rugby players. [Clin J Sport Med. 2010]</p></blockquote><p></p>
[QUOTE="Nelson Vergel, post: 27031, member: 3"] Here are some good discussions from the past on the subject of increasing DHT [B][URL="https://www.excelmale.com/forum/showthread.php?1051-Scrotum-application-of-testosterone"]Scrotum application of testosterone[/URL][/B] This is a German product that some guys import into the US: [B][URL="https://www.excelmale.com/forum/showthread.php?1869-DHT-Gel-Shuts-Down-LH-FSH-Estradiol-and-T-But-Sustained-Sexual-Function"]DHT Gel Shuts Down LH, FSH, Estradiol and T But Sustained Sexual Function[/URL][/B] and here is an interesting study with creatine: Clin J Sport Med. 2009 Sep;19(5):399-404. [B]Three weeks of creatine monohydrate supplementation affects dihydrotestosterone to testosterone ratio in college-aged rugby players.[/B] van der Merwe J1, Brooks NE, Myburgh KH. Abstract OBJECTIVE: This study investigated resting concentrations of selected androgens after 3 weeks of creatine supplementation in male rugby players. It was hypothesized that the ratio of dihydrotestosterone (DHT, a biologically more active androgen) to testosterone (T) would change with creatine supplementation. DESIGN: Double-blind placebo-controlled crossover study with a 6-week washout period. SETTING: Rugby Institute in South Africa. PARTICIPANTS: College-aged rugby players (n = 20) volunteered for the study, which took place during the competitive season. INTERVENTIONS: Subjects loaded with creatine (25 g/day creatine with 25 g/day glucose) or placebo (50 g/day glucose) for 7 days followed by 14 days of maintenance (5 g/day creatine with 25 g/day glucose or 30 g/day glucose placebo). MAIN OUTCOME MEASURES: Serum T and DHT were measured and ratio calculated at baseline and after 7 days and 21 days of creatine supplementation (or placebo). Body composition measurements were taken at each time point. RESULTS: After 7 days of creatine loading, or a further 14 days of creatine maintenance dose, serum T levels did not change. However, levels of DHT increased by 56% after 7 days of creatine loading and remained 40% above baseline after 14 days maintenance (P < 0.001). The ratio of DHT:T also increased by 36% after 7 days creatine supplementation and remained elevated by 22% after the maintenance dose (P < 0.01). CONCLUSIONS: Creatine supplementation may, in part, act through an increased rate of conversion of T to DHT. Further investigation is warranted as a result of the high frequency of individuals using creatine supplementation and the long-term safety of alterations in circulating androgen composition. STATEMENT OF CLINICAL RELEVANCE: Although creatine is a widely used ergogenic aid, the mechanisms of action are incompletely understood, particularly in relation to dihydrotestosterone, and therefore the long-term clinical safety cannot be guaranteed. Comment in Creatine supplementation and DHT:T ratio in male rugby players. [Clin J Sport Med. 2010] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Re: (low) DHT...anyone using cream + injections
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