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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Raloxifene for High E2?
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<blockquote data-quote="Cataceous" data-source="post: 220352" data-attributes="member: 38109"><p>Raloxifene is a SERM—selective estrogen receptor modulator. These medications block estrogen's access to certain receptors, selectively reducing or increasing estrogenic activity. They do not reduce the level of estrogen. In contrast, an aromatase inhibitor such as anastrozole blocks the formation of estradiol, decreasing levels and reducing all estrogenic activity. One problem with SERMs is that the precise effects are a little difficult to ascertain. There's a <a href="https://en.wikipedia.org/wiki/Selective_estrogen_receptor_modulator#Pharmacology" target="_blank">table</a> on Wikipedia listing some tissue-specific effects. You'll see that raloxifene is anti-estrogenic in the breasts, estrogenic in the bones and liver, and shows mixed activity in the brain. SERMs can be helpful if they happen to reduce estrogenic activity where you need it reduced.</p><p></p><p>What you need to figure out is whether your bad reaction is to anastrozole itself or to the lower level of estrogens. There are various other AIs you could substitute if your reaction is only to the particular drug. For example: exemestane or letrozole.</p><p></p><p>Personally I wouldn't be comfortable with such a high dose of testosterone in the long run. You might consider experimenting with some intermediate doses to see if you can find a lower level that maintains the ostensible benefits of the higher dose.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 220352, member: 38109"] Raloxifene is a SERM—selective estrogen receptor modulator. These medications block estrogen's access to certain receptors, selectively reducing or increasing estrogenic activity. They do not reduce the level of estrogen. In contrast, an aromatase inhibitor such as anastrozole blocks the formation of estradiol, decreasing levels and reducing all estrogenic activity. One problem with SERMs is that the precise effects are a little difficult to ascertain. There's a [URL='https://en.wikipedia.org/wiki/Selective_estrogen_receptor_modulator#Pharmacology']table[/URL] on Wikipedia listing some tissue-specific effects. You'll see that raloxifene is anti-estrogenic in the breasts, estrogenic in the bones and liver, and shows mixed activity in the brain. SERMs can be helpful if they happen to reduce estrogenic activity where you need it reduced. What you need to figure out is whether your bad reaction is to anastrozole itself or to the lower level of estrogens. There are various other AIs you could substitute if your reaction is only to the particular drug. For example: exemestane or letrozole. Personally I wouldn't be comfortable with such a high dose of testosterone in the long run. You might consider experimenting with some intermediate doses to see if you can find a lower level that maintains the ostensible benefits of the higher dose. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Raloxifene for High E2?
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