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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Raising SHBG using raloxifene
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<blockquote data-quote="Cataceous" data-source="post: 250418" data-attributes="member: 38109"><p>Anecdotally, clomiphene is notorious for significantly raising SHBG. It's probably caused by the estrogenic zuclomiphene isomer, as the clinical trials on enclomiphene showed no change. I see that at least <a href="https://pubmed.ncbi.nlm.nih.gov/16775175/" target="_blank">in women</a> raloxifene leads to a modest increase in SHBG and a more significant rise in estradiol. This begs the question, was the increase in SHBG caused directly by raloxifene, or indirectly through the increase in estradiol?</p><p></p><p>There's some belief that switching to propionate from equivalent doses of a longer ester results in less estrogenic activity. If this is the case then you will find it counterproductive with respect to raising SHBG.</p><p></p><p>Because androgens tend to suppress SHBG, reducing your testosterone dose may be the safest way to increase SHBG.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 250418, member: 38109"] Anecdotally, clomiphene is notorious for significantly raising SHBG. It's probably caused by the estrogenic zuclomiphene isomer, as the clinical trials on enclomiphene showed no change. I see that at least [URL='https://pubmed.ncbi.nlm.nih.gov/16775175/']in women[/URL] raloxifene leads to a modest increase in SHBG and a more significant rise in estradiol. This begs the question, was the increase in SHBG caused directly by raloxifene, or indirectly through the increase in estradiol? There's some belief that switching to propionate from equivalent doses of a longer ester results in less estrogenic activity. If this is the case then you will find it counterproductive with respect to raising SHBG. Because androgens tend to suppress SHBG, reducing your testosterone dose may be the safest way to increase SHBG. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Raising SHBG using raloxifene
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