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General Health & Fitness
Nutrition and Supplements
Raising IGF-1 raised my PSA
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<blockquote data-quote="DragonBits" data-source="post: 124263" data-attributes="member: 18023"><p>I believe TRT in general can cause a small rise in PSA. Your rise in IGF-1 was dramatic, PSA rise was fairly small, I have seen such fluctuations over time in my PSA scores even then I was not taking any hormones.</p><p></p><p>Dhea, IGF-1, DHT all involved in the prostate. IMO it's difficult to determine what is affecting what and studies are conflicting.</p><p></p><p>EDIT: Even estrogen is involved in some way with BPH and the prostate. </p><p></p><p><a href="https://www.excelmale.com/forum/threads/testosterone-dht-and-prostate-enlargement.16435/" target="_blank">Testosterone(DHT) and Prostate Enlargement</a></p><p></p><p>=================================================</p><p></p><p>Conclusions. These data suggest that DHEA administration to prostate cancer cells can affect PSA, AR and IGF-IR protein expression similar to that of T and DHT, but with a diminished and delayed response. The mechanisms underlying these DHEA-modulated effects, and their potential implications for persons with unrevealed prostate cancer remain to be elucidated</p><p></p><p><a href="https://www.eusupplements.europeanurology.com/article/S1569-9056(03)90462-3/pdf" target="_blank">https://www.eusupplements.europeanurology.com/article/S1569-9056(03)90462-3/pdf</a></p></blockquote><p></p>
[QUOTE="DragonBits, post: 124263, member: 18023"] I believe TRT in general can cause a small rise in PSA. Your rise in IGF-1 was dramatic, PSA rise was fairly small, I have seen such fluctuations over time in my PSA scores even then I was not taking any hormones. Dhea, IGF-1, DHT all involved in the prostate. IMO it's difficult to determine what is affecting what and studies are conflicting. EDIT: Even estrogen is involved in some way with BPH and the prostate. [URL="https://www.excelmale.com/forum/threads/testosterone-dht-and-prostate-enlargement.16435/"]Testosterone(DHT) and Prostate Enlargement[/URL] ================================================= Conclusions. These data suggest that DHEA administration to prostate cancer cells can affect PSA, AR and IGF-IR protein expression similar to that of T and DHT, but with a diminished and delayed response. The mechanisms underlying these DHEA-modulated effects, and their potential implications for persons with unrevealed prostate cancer remain to be elucidated [URL]https://www.eusupplements.europeanurology.com/article/S1569-9056(03)90462-3/pdf[/URL] [/QUOTE]
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Raising IGF-1 raised my PSA
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