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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Question on recent labs
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<blockquote data-quote="Cataceous" data-source="post: 191187" data-attributes="member: 38109"><p>The apparent "high test numbers" achieved with more frequent injections are somewhat of an illusion. For the same total weekly dose of testosterone the <em>average</em> serum level is going to be about the same, whether you're injecting weekly or daily. The problem is that the troughs measured with weekly injections are much lower than the average. Meanwhile, the post-injection peaks are almost ridiculously high. For example, a guy measures a trough of 500 ng/dL on weekly injections of 70 mg TC. He switches to daily injections of 10 mg TC and now measures serum testosterone at 1,000 ng/dL. He thinks, "Wow, daily injections doubled my testosterone!" But in reality, with weekly injections his post-injection peak was 1,500 ng/dL, and levels would decline over the week to 500 ng/dL. But the average is still 1,000 ng/dL with either injection schedule.</p><p></p><p>This is directly applicable to your situation. Let's assume you're seeing little hormonal variation on EOD dosing, so your average serum testosterone is about 1,000 ng/dL. If you switch to E3.5D injections with the same total weekly doses then you might start measuring troughs around 800 ng/dL. Your peaks could be around 1,200 ng/dL. The average stays at 1,000.</p><p></p><p>This may not improve the side effects of excessive dosing, and could make them worse due to the higher peaks. You still want the dose reduction to put your peaks somewhere below 1,000 ng/dL, while not letting the troughs get too low. It's an extra variable to fuss with, which is a point in favor of dialing in with frequent injections before experimenting with greater swings in serum testosterone.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 191187, member: 38109"] The apparent "high test numbers" achieved with more frequent injections are somewhat of an illusion. For the same total weekly dose of testosterone the [I]average[/I] serum level is going to be about the same, whether you're injecting weekly or daily. The problem is that the troughs measured with weekly injections are much lower than the average. Meanwhile, the post-injection peaks are almost ridiculously high. For example, a guy measures a trough of 500 ng/dL on weekly injections of 70 mg TC. He switches to daily injections of 10 mg TC and now measures serum testosterone at 1,000 ng/dL. He thinks, "Wow, daily injections doubled my testosterone!" But in reality, with weekly injections his post-injection peak was 1,500 ng/dL, and levels would decline over the week to 500 ng/dL. But the average is still 1,000 ng/dL with either injection schedule. This is directly applicable to your situation. Let's assume you're seeing little hormonal variation on EOD dosing, so your average serum testosterone is about 1,000 ng/dL. If you switch to E3.5D injections with the same total weekly doses then you might start measuring troughs around 800 ng/dL. Your peaks could be around 1,200 ng/dL. The average stays at 1,000. This may not improve the side effects of excessive dosing, and could make them worse due to the higher peaks. You still want the dose reduction to put your peaks somewhere below 1,000 ng/dL, while not letting the troughs get too low. It's an extra variable to fuss with, which is a point in favor of dialing in with frequent injections before experimenting with greater swings in serum testosterone. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Question on recent labs
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