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If the implication is supposed to be that guys with higher SHBG have testosterone falling more slowly than if they had lower SHBG then I'd really like to see someone defend this line of thought. To me it seems as though SHBG influences the clearance rate of testosterone, which in turn controls the observed serum levels: higher with high SHBG, lower with low. But the rate of decline of serum levels is mainly controlled by the ester release rate, which is pretty independent of SHBG.

[QUOTE="Cataceous, post: 143577, member: 38109"] If the implication is supposed to be that guys with higher SHBG have testosterone falling more slowly than if they had lower SHBG then I'd really like to see someone defend this line of thought. To me it seems as though SHBG influences the clearance rate of testosterone, which in turn controls the observed serum levels: higher with high SHBG, lower with low. But the rate of decline of serum levels is mainly controlled by the ester release rate, which is pretty independent of SHBG. [/QUOTE]

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TRT Hormone Predictor Widget

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038