Again if blood health markers are good than it is highly unlikely running such doses in the short-term would be harmful and as far as long-term no one can say for sure.
Most of the minor cosmetic side-effects (oily skin/acne, MPH (genetically prone), water retention, gyno (genetically prone), testicular atrophy are usually temporary and can be controlled/managed to a certain degree through the use of ancillaries.
If anything long-term would be possible cardiovascular damage, liver damage (only with use of c-17 alpha alkylated orals) and permanent dysfunction of the hpta.
That said ones genetics/lifestyle would also play a big role.
Regardless of running higher doses even if blood health markers are good.....no healthy young male naturally produces T levels (TT/FT) that high 2000+
