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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Question about natural production
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<blockquote data-quote="Cataceous" data-source="post: 194946" data-attributes="member: 38109"><p>Low SHBG can be a challenge for guys on TRT. The exact reasons why are not definitively explained. Low SHBG does not affect the absorption rate of exogenous testosterone. It also can't change the overall metabolic clearance rate of testosterone because that is governed by the absorption rate. With respect to a fixed TRT dose, low SHBG does make free estradiol higher relative to free testosterone, and it reduces total testosterone. There's also speculation that a dearth of intracellular SHBG leads to inefficient utilization of testosterone.</p><p></p><p>Historically, in research exogenous testosterone was radiolabeled—made radioactive—so that its concentration relative to endogenous testosterone could be measured. A newer method is to label exogenous testosterone with deuterium. Testing via mass spectrometry can then differentiate between the labeled testosterone and the unlabeled natural testosterone.</p><p></p><p>A method more accessible to the average guy is to determine his dose-response relationship for exogenous testosterone. Generally free testosterone is proportional to dose. Once the constant of proportionality is known then it's possible to calculate the relative amounts of endogenous and exogenous testosterone based on dose and free testosterone.</p><p></p><p>As I mentioned above, any longer lasting—more than a few hours—exogenous testosterone is considerably more suppressive than endogenous testosterone. So you shouldn't be surprised to find that each milligram of exogenous testosterone can reduce endogenous production by more than one milligram, and perhaps much more.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 194946, member: 38109"] Low SHBG can be a challenge for guys on TRT. The exact reasons why are not definitively explained. Low SHBG does not affect the absorption rate of exogenous testosterone. It also can't change the overall metabolic clearance rate of testosterone because that is governed by the absorption rate. With respect to a fixed TRT dose, low SHBG does make free estradiol higher relative to free testosterone, and it reduces total testosterone. There's also speculation that a dearth of intracellular SHBG leads to inefficient utilization of testosterone. Historically, in research exogenous testosterone was radiolabeled—made radioactive—so that its concentration relative to endogenous testosterone could be measured. A newer method is to label exogenous testosterone with deuterium. Testing via mass spectrometry can then differentiate between the labeled testosterone and the unlabeled natural testosterone. A method more accessible to the average guy is to determine his dose-response relationship for exogenous testosterone. Generally free testosterone is proportional to dose. Once the constant of proportionality is known then it's possible to calculate the relative amounts of endogenous and exogenous testosterone based on dose and free testosterone. As I mentioned above, any longer lasting—more than a few hours—exogenous testosterone is considerably more suppressive than endogenous testosterone. So you shouldn't be surprised to find that each milligram of exogenous testosterone can reduce endogenous production by more than one milligram, and perhaps much more. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Question about natural production
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