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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Question about my TRT current protocol
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<blockquote data-quote="Cataceous" data-source="post: 229092" data-attributes="member: 38109"><p><a href="http://www.issam.ch/freetesto.htm" target="_blank">Here's</a> a commonly used implementation of the Vermeulen free T calculation. You have four parameters: total testosterone, free testosterone, SHBG and albumin. Each can be estimated if the other three parameters are known. Typically free testosterone is treated as the unknown because it's the most difficult to measure accurately. Using default albumin, your—trough—calculated free testosterone is 15.6 ng/dL. The average for healthy young men is about 15. Unless your free testosterone was measured using equilibrium dialysis or ultrafiltration the value is inaccurate and should be disregarded. Your total hormones are low because your SHBG is very low. The total hormones have less bearing on your results than the free hormone levels. Total estradiol of 17 pg/mL is ok in your situation because free estradiol is estimated to be 0.5 pg/mL—in the normal range of about 0.3-1.2 pg/mL. Your peak value is probably much higher.</p><p></p><p>I think you should reduce the dose and inject more often. Your average free testosterone is probably 25-30 ng/dL. Top-of-range is about 22 ng/dL. I think you should get free T down closer to 15 ng/dL and see how that feels. Ideally you'd inject frequently enough to avoid substantial variation over multiple days. Some intraday variation is natural and maybe even desirable. If it were me I would try 20 mg of cypionate every other day.</p><p></p><p>The more-plates-more-dates guy is comparable in spite of the differences. We don't know his SHBG and thus have no idea about free hormones—he didn't measure free testosterone by an accurate method. He is injecting daily. He is injecting a different ester with a much shorter half-life. He's probably also measuring at trough. In terms of hormonal variation, his daily injections are similar to your weekly injections. At least for myself I estimate peak hormone levels with daily propionate to be about three times the trough levels. Therefore he is also disregarding very high hormone levels earlier in the injection cycle.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 229092, member: 38109"] [URL='http://www.issam.ch/freetesto.htm']Here's[/URL] a commonly used implementation of the Vermeulen free T calculation. You have four parameters: total testosterone, free testosterone, SHBG and albumin. Each can be estimated if the other three parameters are known. Typically free testosterone is treated as the unknown because it's the most difficult to measure accurately. Using default albumin, your—trough—calculated free testosterone is 15.6 ng/dL. The average for healthy young men is about 15. Unless your free testosterone was measured using equilibrium dialysis or ultrafiltration the value is inaccurate and should be disregarded. Your total hormones are low because your SHBG is very low. The total hormones have less bearing on your results than the free hormone levels. Total estradiol of 17 pg/mL is ok in your situation because free estradiol is estimated to be 0.5 pg/mL—in the normal range of about 0.3-1.2 pg/mL. Your peak value is probably much higher. I think you should reduce the dose and inject more often. Your average free testosterone is probably 25-30 ng/dL. Top-of-range is about 22 ng/dL. I think you should get free T down closer to 15 ng/dL and see how that feels. Ideally you'd inject frequently enough to avoid substantial variation over multiple days. Some intraday variation is natural and maybe even desirable. If it were me I would try 20 mg of cypionate every other day. The more-plates-more-dates guy is comparable in spite of the differences. We don't know his SHBG and thus have no idea about free hormones—he didn't measure free testosterone by an accurate method. He is injecting daily. He is injecting a different ester with a much shorter half-life. He's probably also measuring at trough. In terms of hormonal variation, his daily injections are similar to your weekly injections. At least for myself I estimate peak hormone levels with daily propionate to be about three times the trough levels. Therefore he is also disregarding very high hormone levels earlier in the injection cycle. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Question about my TRT current protocol
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