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You've got to track your symptoms along with your numbers, or you'll end up chasing numbers forever. I don't think there's any two men on this forum that do everything 100% the same. An E2 of 33 could be fine for some of us, it could be terrible for others. Some of us want our E2 within a ratio of our testosterone, others go E2 to SHBG (which there is no published study to support, but two different PA's at Defy that I know of recommend that method and it's the one that works for me personally). Journal everything and let symptoms guide you. Numbers are ALWAYS secondary.