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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Question about estradiol
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<blockquote data-quote="Cataceous" data-source="post: 172582" data-attributes="member: 38109"><p>The guys pushing the sensitive, mass spectrometry-based estradiol tests have good intentions, but the situation is more complex than it sounds, and everyone should know a little about the tradeoffs. </p><p></p><p>A sensitive test is capable of being very accurate <em>provided it's done perfectly</em>. But the equipment and methods are quite complicated and finicky, leading to a relatively high rate of very large errors. For example, 30% of my sensitive results have had no relationship with reality.</p><p></p><p>The non-sensitive, standard immunoassay tests are simple and idiot-proof, highly reliable and repeatable. The problem is that their specificity is lacking—other substances can falsely elevate the readings. Most guys should find these effects are small, maybe a pretty consistent five or 10 percent elevation.</p><p></p><p>The ideal situation is to use both methods, at least initially, until a pattern is clear. After performing this "calibration", I now rely exclusively on the non-sensitive test.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 172582, member: 38109"] The guys pushing the sensitive, mass spectrometry-based estradiol tests have good intentions, but the situation is more complex than it sounds, and everyone should know a little about the tradeoffs. A sensitive test is capable of being very accurate [I]provided it's done perfectly[/I]. But the equipment and methods are quite complicated and finicky, leading to a relatively high rate of very large errors. For example, 30% of my sensitive results have had no relationship with reality. The non-sensitive, standard immunoassay tests are simple and idiot-proof, highly reliable and repeatable. The problem is that their specificity is lacking—other substances can falsely elevate the readings. Most guys should find these effects are small, maybe a pretty consistent five or 10 percent elevation. The ideal situation is to use both methods, at least initially, until a pattern is clear. After performing this "calibration", I now rely exclusively on the non-sensitive test. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Question about estradiol
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