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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Question about estradiol and the sensitive estradiol test
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<blockquote data-quote="hdrider" data-source="post: 24505" data-attributes="member: 574"><p>Vince,</p><p></p><p>If E2 binds to SHBG in a similar way to T, then that would seem to be a big factor in how guys react to a given E2 number (again total E2, both bound and unbound? I'm not sure what the sensitive E2 test actually measures...) And it does not make sense to me that therefore there is only one E2 number, since from what I understand, some E2 is bound and some is unbound.</p><p></p><p>I'm just asking questions to help my understanding.</p><p> </p><p>I do understand the ratio theory: That what is important is not the E2 number but the ratio of T to E2. However, according to Dr. John Crisler in his book (Chapter 5), he disagrees with that theory. (Unless he has changed his mind, and I understand that this is a rapidly evolving area as we all continue to learn.)</p><p></p><p>Dr. Crisler says in his book:</p><p></p><p>"Some believe it is only the T/E ratio which is significant, and therefore, as long as E only 'appropriately' rises with elevations in T, all is well. This is incorrect, as the absolute concentration of estrogen (actually, all of them) is of concern, too. Now especially so in light of data pointing to elevated estrogen as cause, or adjunctively encouraging, several serious disease processes, including numerous cancers, as well as significant potential for induction of sexual dysfunction (no matter the accompanying androgen load)..."</p><p></p><p>The practical question is whether lowering my E2 is going to help me with my problem. I guess I will find out in another month or so as the new protocol takes hold.</p></blockquote><p></p>
[QUOTE="hdrider, post: 24505, member: 574"] Vince, If E2 binds to SHBG in a similar way to T, then that would seem to be a big factor in how guys react to a given E2 number (again total E2, both bound and unbound? I'm not sure what the sensitive E2 test actually measures...) And it does not make sense to me that therefore there is only one E2 number, since from what I understand, some E2 is bound and some is unbound. I'm just asking questions to help my understanding. I do understand the ratio theory: That what is important is not the E2 number but the ratio of T to E2. However, according to Dr. John Crisler in his book (Chapter 5), he disagrees with that theory. (Unless he has changed his mind, and I understand that this is a rapidly evolving area as we all continue to learn.) Dr. Crisler says in his book: "Some believe it is only the T/E ratio which is significant, and therefore, as long as E only 'appropriately' rises with elevations in T, all is well. This is incorrect, as the absolute concentration of estrogen (actually, all of them) is of concern, too. Now especially so in light of data pointing to elevated estrogen as cause, or adjunctively encouraging, several serious disease processes, including numerous cancers, as well as significant potential for induction of sexual dysfunction (no matter the accompanying androgen load)..." The practical question is whether lowering my E2 is going to help me with my problem. I guess I will find out in another month or so as the new protocol takes hold. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Question about estradiol and the sensitive estradiol test
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