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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Question about E2 and Testosterone Percentage in the Body
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<blockquote data-quote="Cataceous" data-source="post: 175056" data-attributes="member: 38109"><p>Both positions ignore the nuances. Estradiol is also produced in the brain, arterial walls, bone and liver. It cannot be said that aromatase inhibitors affect these areas equally. Interestingly, different aromatase inhibitors have varying abilities to affect brain aromatization. Anastrozole is said to have relatively less activity there, possibly making it safer in this regard. At the same time, it's clearly ridiculous to state that any amount of an AI must be harmful. This is not supported by the evidence. The evidence for risk from high estradiol remains contradictory, and until this is cleared up I think it's best to avoid excessive levels, especially when they are not balanced by testosterone.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 175056, member: 38109"] Both positions ignore the nuances. Estradiol is also produced in the brain, arterial walls, bone and liver. It cannot be said that aromatase inhibitors affect these areas equally. Interestingly, different aromatase inhibitors have varying abilities to affect brain aromatization. Anastrozole is said to have relatively less activity there, possibly making it safer in this regard. At the same time, it's clearly ridiculous to state that any amount of an AI must be harmful. This is not supported by the evidence. The evidence for risk from high estradiol remains contradictory, and until this is cleared up I think it's best to avoid excessive levels, especially when they are not balanced by testosterone. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Question about E2 and Testosterone Percentage in the Body
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