Quest Diagnostics Ultrasensitive Estradiol Code

The aforementioned thread by Nelson is a great post, emphasizing you MUST run the more sensitive estradiol assay. The standard assay is not valid for adult males, and usually over-estimates the true E concentration. This may lead to inappropriate use of an aromatase inhibitor, to the detriment of the patient.

The Quest Ultrasensitive E2 is the preferred LC/MS laboratory methodology. The LabCorp Sensitive Estradiol is an immunoassay, which is inferior, but my clinical experience shows it is usually okay. LabCorp now has a new line of LC/MS assays for the hormonal assays we need; the specific LabCorp codes for you are here:

Testosterone, Bioavailable w/ SHBG #500650
DHEA-S #500161
Estradiol #500108
Estrone #500634

CBC #005009
Comprehensive Metabolic Panel #322000
FSH and LH #028480
DHT #500142
Prolactin #004465
PSA #010322
Progesterone #500167
Pregnenolone #140707
Ferritin #004598
TSH # 004259
Free T4 #501902
Free T3 #503600
reverseT3 #070104
IGF-1 #010363
IGFBP-3 #140152
Vitamin D, 25-Hydroxy #081950


I prefer the Free T4 and Free T3 assays, as they remove the influences of Thyroid Binding Globulin.
 
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hCG Mixing Calculator

HCG Mixing Protocol Calculator

TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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